共 66 条
Cortical Dopamine Release During a Behavioral Response Inhibition Task
被引:34
作者:
Albrecht, Daniel S.
[1
,2
]
Kareken, David A.
[1
,2
,3
,4
]
Christian, Bradley T.
[5
]
Dzemidzic, Mario
[1
,3
,4
]
Yoder, Karmen K.
[1
,2
,3
]
机构:
[1] Indiana Univ Sch Med, Dept Radiol & Imaging Sci, Indianapolis, IN 46202 USA
[2] Indiana Univ Sch Med, Stark Neurosci Res Inst, Indianapolis, IN 46202 USA
[3] Indiana Univ Sch Med, Ctr Neuroimaging, Indianapolis, IN 46202 USA
[4] Indiana Univ Sch Med, Dept Neurol, Indianapolis, IN 46202 USA
[5] Univ Wisconsin, Waisman Ctr, Madison, WI 53705 USA
来源:
关键词:
dopamine;
positron emission tomography;
fallypride;
stop signal task;
D2;
receptor;
impulsivity;
STOP-SIGNAL TASK;
INFERIOR FRONTAL GYRUS;
ALCOHOL DEPENDENCE;
PREFRONTAL CORTEX;
DRUG-USE;
IMPULSIVITY;
PET;
DEACTIVATION;
ATOMOXETINE;
MODULATION;
D O I:
10.1002/syn.21736
中图分类号:
Q189 [神经科学];
学科分类号:
071006 ;
摘要:
Dopamine (DA) dysregulation within fronto-striatal circuitry may underlie impulsivity in alcohol and other substance use disorders. To date, no one has directly demonstrated DA release during a task requiring the control of impulsive behavior. The current study was conducted to determine whether a response inhibition task (stop signal task; SST) would elicit detectable extrastriatal DA release in healthy controls. We hypothesized that DA release would be detected in regions previously implicated in different aspects of inhibitory control. [F-18]Fallypride (FAL) PET imaging was performed in nine healthy males (24.6 +/- 4.1 y.o.) to assess changes in cortical DA during a SST relative to a baseline Go task. On separate days, subjects received one FAL scan during the SST, and one FAL scan during a Go control; task-order was counter-balanced across subjects. Parametric BPND images were generated and analyzed with SPM8. Voxel-wise analysis indicated significant SST-induced DA release in several cortical regions involved in inhibitory control, including the insula, cingulate cortex, orbitofrontal cortex, precuneus, and supplementary motor area. There was a significant positive correlation between stop signal reaction time and DA release in the left orbitofrontal cortex, right middle frontal gyrus, and right precentral gyrus. These data support the feasibility of using FAL PET to study DA release during response inhibition, enabling investigation of relationships between DA function and impulsive behavior. Synapse 68:266-274, 2014. (c) 2014 Wiley Periodicals, Inc.
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页码:266 / 274
页数:9
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