The ideal blood pressure target to prevent cardiovascular disease in type 2 diabetes: A neutral viewpoint

被引：3

作者：

Frontoni, S. ^{[1
]}

Solini, A. ^{[2
]}

Fioretto, P. ^{[3
]}

Natali, A. ^{[2
]}

Zuccala, A. ^{[4
]}

Cosentino, F. ^{[5
]}

Penno, G. ^{[6
]}

机构：

[1] Univ Rome Tor Vergata AFAR, Fatebenefratelli Hosp, Dept Syst Med, Rome, Italy

[2] Univ Pisa, Dept Clin & Expt Med, Pisa, Italy

[3] Univ Padua, Dept Med, Padua, Italy

[4] Civil Hosp Imola, Nephrol Dialysis Unit, Imola, Italy

[5] Univ Roma La Sapienza, Dept Clin & Mol Med, I-00185 Rome, Italy

[6] Univ Pisa, Sect Diabet & Metab Dis, Dept Clin & Expt Med, Pisa, Italy

来源：

NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES | 2014年 / 24卷 / 06期

关键词：

Anti-hypertensive treatment; Blood pressure target; J-shaped curve; Type; 2; diabetes; Elderly; HYPERTENSIVE PATIENTS; HEART-DISEASE; TASK-FORCE; RISK; OUTCOMES; MORTALITY; STROKE; RETINOPATHY; MANAGEMENT; MELLITUS;

D O I：

10.1016/j.numecd.2014.01.004

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Type 2 diabetes mellitus (T2DM) and essential hypertension are often associated, and retrospective data analyses suggest an association between lower blood pressure (BP) values and lower cardiovascular (CV) risk in patients with T2DM. However, the most recent intervention trials fail to demonstrate a further CV risk reduction, for BP levels <130/80 mm Hg, when compared to levels < 140/90 mm Hg. Moreover, a J-shaped, rather than a linear, relationship of BP reduction with incident CV events has been strongly suggested. We here debate the main available evidences for and against the concept of 'he lower the better', in the light of the main intervention trials and meta-analyses, with a particular emphasis on the targets to be pursued in elderly patients. Finally, the most recent guidelines of the scientific societies are critically discussed. (C) 2014 Elsevier B. V. All rights reserved.

引用

页码：577 / 584

页数：8

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