Novel inhalational murine model of invasive pulmonmy aspergillosis

被引：112

作者：

Sheppard, DC

Rieg, G

Chiang, LY

Filler, SG

Edwards, JE

Ibrahim, AS

机构：

[1] Harbor UCLA Res & Educ Inst, Div Infect Dis, St Johns Cardiovasc Res Ctr, Dept Med, Torrance, CA 90502 USA

[2] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90024 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2004年 / 48卷 / 05期

关键词：

D O I：

10.1128/AAC.48.5.1908-1911.2004

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We developed a novel model of invasive aspergillosis (IA) that recapitulates human disease. Mice were immunosuppressed with cyclophosphamide and cortisone acetate and then infected in an aerosol chamber. This procedure reproducibly delivered 1x10(3) to 3x10(3) conidia to the lungs. Lethal pulmonary IA developed over 2 weeks and was prevented by amphotericin B.

引用

页码：1908 / 1911

页数：4

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