A novel H-phosphonate method for the synthesis of D-man nose-1-phosphate

被引：0
|
作者：
Li, Xingjian [1 ]
Gong, Shanshan [1 ]
Sun, Qi [1 ]
机构：
[1] Jiangxi Sci & Technol Normal Univ, Jiangxi Key Lab Organ Chem, Nanchang 330013, Jiangxi, Peoples R China
来源：
MECHANICAL ENGINEERING, MATERIALS AND ENERGY III | 2014年 / 483卷
关键词：
H-Phosphonate nnonoester; Mannose-1-phosphate; Phosphitylation; Deacetylation; POTENTIAL CHAIN-TERMINATORS; CHEMICAL-SYNTHESIS;
D O I：
10.4028/www.scientific.net/AMM.483.88
中图分类号：
TH [机械、仪表工业];
学科分类号：
0802 ;
摘要：
A novel and efficient method for the preparation of alpha-D-mannose-1-phosphate has been developed. Phosphitylation of tetraacetylated D-mannose, hydrolysis yielded H-phosphonate nionoester. Silylation of H-phosphonate, followed by oxidative coupling and hydrolysis gave protected D-mannose-1-phosphate. Finally, deprotection of tetraacetylated D-mannose-1-phosphate afforded D-mannose-1-phosphate in excellent yield.
引用
收藏
页码：88 / 91
页数：4
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