A novel H-phosphonate method for the synthesis of D-man nose-1-phosphate

被引：0

作者：

Li, Xingjian ^{[1
]}

Gong, Shanshan ^{[1
]}

Sun, Qi ^{[1
]}

机构：

[1] Jiangxi Sci & Technol Normal Univ, Jiangxi Key Lab Organ Chem, Nanchang 330013, Jiangxi, Peoples R China

来源：

MECHANICAL ENGINEERING, MATERIALS AND ENERGY III | 2014年 / 483卷

关键词：

H-Phosphonate nnonoester; Mannose-1-phosphate; Phosphitylation; Deacetylation; POTENTIAL CHAIN-TERMINATORS; CHEMICAL-SYNTHESIS;

D O I：

10.4028/www.scientific.net/AMM.483.88

中图分类号：

TH [机械、仪表工业];

学科分类号：

0802 ;

摘要：

A novel and efficient method for the preparation of alpha-D-mannose-1-phosphate has been developed. Phosphitylation of tetraacetylated D-mannose, hydrolysis yielded H-phosphonate nionoester. Silylation of H-phosphonate, followed by oxidative coupling and hydrolysis gave protected D-mannose-1-phosphate. Finally, deprotection of tetraacetylated D-mannose-1-phosphate afforded D-mannose-1-phosphate in excellent yield.

引用

页码：88 / 91

页数：4

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