OSSC1E-K19, a novel phytochemical component of Osteomeles schwerinae, prevents glycated albumin-induced retinal vascular injury in rats

被引：2
作者：
Kim, Chan-Sik [1 ]
Kim, Junghyun [1 ]
Jo, Kyuhyung [1 ]
Lee, Yun Mi [1 ]
Sohn, Eunjin [1 ]
Yoo, Nam Hee [2 ]
Kim, Jin Sook [1 ]
机构：
[1] Korea Inst Oriental Med, Herbal Med Res Div, Korean Med Based Herbal Drug Dev Grp, Taejon 305811, South Korea
[2] Int Ginseng & Herb Res Inst, Korea Nat Prod Dev Lab, Geumsan 312804, South Chungcheo, South Korea
来源：
MOLECULAR MEDICINE REPORTS | 2015年 / 12卷 / 05期
关键词：
Osteomeles schwerinae; diabetic retinopathy; advanced glycation end products; vascular endothelial growth factor; blood-retinal barrier; ENDOTHELIAL GROWTH-FACTOR; END-PRODUCTS; DIABETIC-RETINOPATHY; PERMEABILITY; BARRIER; AMINOGUANIDINE; OCCLUDIN; DYSFUNCTION; APOPTOSIS; BREAKDOWN;
D O I：
10.3892/mmr.2015.4413
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
In the pathophysiology of diabetic retinopathy (DR), advanced glycation end products (AGEs) and vascular endothelial growth factor (VEGF) are thought to have important roles. It is known that VEGF causes a breakdown of the blood-retinal barrier (BRB) and retinal neovascularization; however, how AGEs affect the retina has largely remained elusive. OSSC1E-K19 is a novel phytochemical component of Osteomeles schwerinae. The objective of the present study was to evaluate the protective effects of OSSC1E-K19 on retinal vascular injury in AGE-modified rat serum albumin (AGE-RSA)-induced retinopathy. AGE-RSA-injected rat eyes were used investigate the protective effects of OSSC1E-K19 on BRB breakdown. Intravitreal injection of OSSC1E-K19 prevented AGE-RSA-induced BRB breakdown and decreased retinal VEGF expression in retinal vessels. In addition, OSSC1E-K19 inhibited the loss of occludin, a significant tight junction protein. These results supported the potential therapeutic utility of OSSC1E-K19 for retinal vascular permeability diseases.
引用
收藏
页码：7279 / 7284
页数：6
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