A randomized placebo-controlled pilot trial shows that intranasal vasopressin improves social deficits in children with autism

被引：105

作者：

Parker, Karen J. ^{[1
]}

Oztan, Ozge ^{[1
]}

Libove, Robin A. ^{[1
]}

Mohsin, Noreen ^{[1
]}

Karhson, Debra S. ^{[1
]}

Sumiyoshi, Raena D. ^{[1
]}

Summers, Jacqueline E. ^{[1
]}

Hinman, Kyle E. ^{[1
]}

Motonaga, Kara S. ^{[2
]}

Phillips, Jennifer M. ^{[1
]}

Carson, Dean S. ^{[1
]}

Fung, Lawrence K. ^{[1
]}

Garner, Joseph P. ^{[1
,3
]}

Hardan, Antonio Y. ^{[1
]}

机构：

[1] Stanford Univ, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA

[2] Stanford Univ, Dept Pediat, Stanford, CA 94305 USA

[3] Stanford Univ, Dept Comparat Med, Stanford, CA 94305 USA

来源：

SCIENCE TRANSLATIONAL MEDICINE | 2019年 / 11卷 / 491期

关键词：

DIAGNOSTIC INTERVIEW; ARGININE-VASOPRESSIN; RECEPTOR; OXYTOCIN; BEHAVIOR; AGGRESSION; TRAITS; INDIVIDUALS; SCALE; 1-DEAMINO-8-D-ARGININE-VASOPRESSIN;

D O I：

10.1126/scitranslmed.aau7356

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The social impairments of autism spectrum disorder (ASD) have a major impact on quality of life, yet there are no medications that effectively treat these core social behavior deficits. Preclinical research suggests that arginine vasopressin (AVP), a neuropeptide involved in promoting mammalian social behaviors, may be a possible treatment for ASD. Using a double-blind, randomized, placebo-controlled, parallel study design, we tested the efficacy and tolerability of a 4-week intranasal AVP daily treatment in 30 children with ASD. AVP-treated participants aged 6 to 9.5 years received the maximum daily target dose of 24 International Units (IU); participants aged 9.6 to 12.9 years received the maximum daily target dose of 32 IU. Intranasal AVP treatment compared to placebo enhanced social abilities as assessed by change from baseline in this phase 2 trial's primary outcome measure, the Social Responsiveness Scale, 2nd Edition total score (SRS-2 T score; F-1,F-20 = 9.853; P = 0.0052;. eta(2)(p) = 33.0%; Cohen's d = 1.40). AVP treatment also diminished anxiety symptoms and some repetitive behaviors. Most of these findings were more pronounced when we accounted for pretreatment AVP concentrations in blood. AVP was well tolerated with minimal side effects. No AVP-treated participants dropped out of the trial, and there were no differences in the rate of adverse events reported between treatment conditions. Last, no changes from baseline were observed in vital signs, electrocardiogram tracings, height and body weight, or clinical chemistry measurements after 4 weeks of AVP treatment. These preliminary findings suggest that AVP has potential for treating social impairments in children with ASD.

引用

页数：12