Inhibition of HSV-1 protease by benzoxazinones

被引：103

作者：

Jarvest, RL ^{[1
]}

Parratt, MJ ^{[1
]}

Debouck, CM ^{[1
]}

Gorniak, JG ^{[1
]}

Jennings, LJ ^{[1
]}

Serafinowska, HT ^{[1
]}

Strickler, JE ^{[1
]}

机构：

[1] SMITHKLINE BEECHAM PHARMACEUT,KING OF PRUSSIA,PA 19406

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 20期

关键词：

D O I：

10.1016/0960-894X(96)00455-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Benzoxazinones have been discovered which are mechanism based inhibitors of HSV-1 protease with micromolar IC50 values. Formation of a monoadduct consistent with the acyl-enzyme complex was detected by mass spectroscopy. A parallel array synthesis was developed to explore 2-heteroatom substituted SAR. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：2463 / 2466

页数：4

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