Phytol-derived novel isoprenoid immunostimulants

被引：28

作者：

Chowdhury, Roshni Roy ^{[1
]}

Ghosh, Swapan K. ^{[1
]}

机构：

[1] Indiana State Univ, Dept Biol, Terre Haute, IN 47809 USA

来源：

FRONTIERS IN IMMUNOLOGY | 2012年 / 3卷

关键词：

immunostimulants; phytol derivatives; isoprenoid adjuvants; activation of innate immunity; vaccine efficacy; cytokine microenvironment; inflammasome; antibody and CTL response; EFFECTIVE DELIVERY-SYSTEM; PROTEIN-KINASE-C; FREUNDS-ADJUVANT; ALUMINUM-HYDROXIDE; ANTIBODY-RESPONSES; VACCINE ADJUVANTS; IMMUNE-SYSTEM; IN-VIVO; CELLS; INDUCTION;

D O I：

10.3389/fimmu.2012.00049

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

This review describes the adjuvanticity of novel diterpenoids (synthetic phytol derivatives) compared to some commercially available adjuvants. The efficacy of the phytol-derived immunostimulants was evaluated in terms of their ability to activate innate immunity, amplify various antigen-specific immune responses, and engender immunological memory with no discernible adverse effects in both competent and immune-deficient mice. The profile that emerges out of these studies reveals that the phytol derivatives are excellent immunostimulants, superior to a number of commercial adjuvants in terms of long-term memory induction and activation of both innate and acquired immunity. Additionally, the phytol-derived compounds have no cumulative inflammatory or toxic effects even in immuno-compromised mice.

引用

页数：11

共 106 条

[21] AS04, an Aluminum Salt- and TLR4 Agonist-Based Adjuvant System, Induces a Transient Localized Innate Immune Response Leading to Enhanced Adaptive Immunity [J].

Didierlaurent, Arnaud M. ;

Morel, Sandra ;

Lockman, Laurence ;

Giannini, Sandra L. ;

Bisteau, Michel ;

Carlsen, Harald ;

Kielland, Anders ;

Vosters, Olivier ;

Vanderheyde, Nathalie ;

Schiavetti, Francesca ;

Larocque, Daniel ;

Van Mechelen, Marcelle ;

Garcon, Nathalie .

JOURNAL OF IMMUNOLOGY, 2009, 183 (10) :6186-6197

[22]

DVORAK AM, 1974, IMMUNOLOGY, V27, P99

[23] THE CHEMOPREVENTION OF CANCER BY MEVALONATE-DERIVED CONSTITUENTS OF FRUITS AND VEGETABLES [J].

ELSON, CE ;

YU, SG .

JOURNAL OF NUTRITION, 1994, 124 (05) :607-614

[24] Adjuvant action of Chenopodium guinea saponins on the induction of antibody responses to intragastric and intranasal administered antigens in mice [J].

Estrada, A ;

Li, B ;

Laarveld, B .

COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES, 1998, 21 (03) :225-236

[25]

Geier D. A., 2009, Toxicological and Environmental Chemistry, V91, P735, DOI 10.1080/02772240802246458

[26]

Ghosh SK, 2012, United States Patent, Patent No. [US8088395, 8088395]

[27] WILD POTATO REPELS APHIDS BY RELEASE OF APHID ALARM PHEROMONE [J].

GIBSON, RW ;

PICKETT, JA .

NATURE, 1983, 302 (5909) :608-609

[28] PRENYL PROTEINS IN EUKARYOTIC CELLS - A NEW TYPE OF MEMBRANE ANCHOR [J].

GLOMSET, JA ;

GELB, MH ;

FARNSWORTH, CC .

TRENDS IN BIOCHEMICAL SCIENCES, 1990, 15 (04) :139-142

[29] MF59 adjuvant enhances antibody responses of infant baboons immunized with Haemophilus influenzae type b and Neisseria meningitidis group C oligosaccharide-CRM197 conjugate vaccine [J].

Granoff, DM ;

McHugh, YE ;

Raff, HV ;

Mokatrin, AS ;

VanNest, GA .

INFECTION AND IMMUNITY, 1997, 65 (05) :1710-1715

[30] ADJUVANTS - A BALANCE BETWEEN TOXICITY AND ADJUVANTICITY [J].

GUPTA, RK ;

RELYVELD, EH ;

LINDBLAD, EB ;

BIZZINI, B ;

BENEFRAIM, S ;

GUPTA, CK .

VACCINE, 1993, 11 (03) :293-306

← 1 2 3 4 5 6 7 8 9 10 →