Phytol-derived novel isoprenoid immunostimulants

被引：28

作者：

Chowdhury, Roshni Roy ^{[1
]}

Ghosh, Swapan K. ^{[1
]}

机构：

[1] Indiana State Univ, Dept Biol, Terre Haute, IN 47809 USA

来源：

FRONTIERS IN IMMUNOLOGY | 2012年 / 3卷

关键词：

immunostimulants; phytol derivatives; isoprenoid adjuvants; activation of innate immunity; vaccine efficacy; cytokine microenvironment; inflammasome; antibody and CTL response; EFFECTIVE DELIVERY-SYSTEM; PROTEIN-KINASE-C; FREUNDS-ADJUVANT; ALUMINUM-HYDROXIDE; ANTIBODY-RESPONSES; VACCINE ADJUVANTS; IMMUNE-SYSTEM; IN-VIVO; CELLS; INDUCTION;

D O I：

10.3389/fimmu.2012.00049

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

This review describes the adjuvanticity of novel diterpenoids (synthetic phytol derivatives) compared to some commercially available adjuvants. The efficacy of the phytol-derived immunostimulants was evaluated in terms of their ability to activate innate immunity, amplify various antigen-specific immune responses, and engender immunological memory with no discernible adverse effects in both competent and immune-deficient mice. The profile that emerges out of these studies reveals that the phytol derivatives are excellent immunostimulants, superior to a number of commercial adjuvants in terms of long-term memory induction and activation of both innate and acquired immunity. Additionally, the phytol-derived compounds have no cumulative inflammatory or toxic effects even in immuno-compromised mice.

引用

页数：11

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