Adaptive Stress Responses During Tumor Metastasis and Dormancy

被引：83

作者：

Senft, Daniela ^{[1
]}

Ronai, Ze'ev A. ^{[1
]}

机构：

[1] NCI, Tumor Initiat & Maintenance Program, Designated Canc Ctr, Sanford Burnham Prebys Med Discovery Inst, La Jolla, CA 92037 USA

来源：

TRENDS IN CANCER | 2016年 / 2卷 / 08期

关键词：

dormancy; metastasis; tumor cell plasticity; unfolded protein response (UPR);

D O I：

10.1016/j.trecan.2016.06.004

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

To survive inhospitable environments, tumor cells are forced to remodel their signaling pathways by altering transcription, translation, and post-translational modifications. This adaptation is regulated in a spatial and temporal manner and gives rise to individual tumor cells with distinct gene expression and metabolic signatures. Such phenotypic heterogeneity is the result of tumor cell plasticity, which-together with the genetic background of the tumor-determines whether cells resist environmental stress, enter dormancy, or metastasize. This review summarizes our understanding of how tumor cells exploit the cellular stress response to balance proliferation, differentiation, and survival signals, as well as to remodel local and distant environments. We focus in particular on tumor metastasis, which is the greatest impediment to clinical management of cancers today.

引用

页码：429 / 442

页数：14

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