Tomographic lifetime imaging using combined early- and late-arriving photons

被引：22

作者：

Hou, Steven S. ^{[1
]}

Rice, William L. ^{[2
]}

Bacskai, Brian J. ^{[1
]}

Kumar, Anand T. N. ^{[2
]}

机构：

[1] Harvard Univ, Sch Med, Alzheimers Dis Res Unit, Massachusetts Gen Hosp,Dept Neurol, Charlestown, MA 02129 USA

[2] Harvard Univ, Sch Med, Dept Radiol, Massachusetts Gen Hosp,Athinoula A Martinos Ctr B, Charlestown, MA 02129 USA

来源：

OPTICS LETTERS | 2014年 / 39卷 / 05期

基金：

美国国家卫生研究院;

关键词：

FLUORESCENCE TOMOGRAPHY; TURBID MEDIA; ALLOWS;

D O I：

10.1364/OL.39.001165

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

We present a novel, hybrid approach for time domain fluorescence tomography that efficiently combines lifetime multiplexing using late-arriving or asymptotic photons, with the high spatial resolution capability of early photon tomography. We also show that a decay amplitude-based asymptotic approach is superior to direct inversion of late-arriving photons for tomographic lifetime imaging within turbid media. The hybrid reconstruction approach is experimentally shown to recover fluorescent inclusions separated as close as 1.4 mm, with improved resolution and reduced cross talk compared to just using early photons or the asymptotic approach alone. (C) 2014 Optical Society of America

引用

页码：1165 / 1168

页数：4

共 15 条

[1] Optical tomography: forward and inverse problems [J].