Potential programming of selected cardiometabolic risk factors at childhood by maternal polyunsaturated fatty acid availability in the MEFAB cohort

被引：8
作者：
Jochems, Sylvia H. J. [1 ,2 ,3 ]
Gielen, Marij [1 ,2 ,3 ]
Rump, Patrick [4 ]
Hornstra, Gerard [5 ]
Zeegers, Maurice P. [1 ,2 ,3 ]
机构：
[1] Maastricht Univ, NUTRIM Sch Nutr & Translat Res Metab, Dept Complex Genet, Maastricht, Netherlands
[2] Maastricht Univ, Dept Cluster Genet, Maastricht, Netherlands
[3] Maastricht Univ, Dept Cell Biol, Maastricht, Netherlands
[4] Univ Groningen, Univ Med Ctr Groningen, Dept Genet, NL-9700 AB Groningen, Netherlands
[5] NUTRI SEARCH, NL-6247 BG Gronsveld, Netherlands
来源：
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS | 2015年 / 100卷
关键词：
Prenatal programming; Fetal origins; Polyunsaturated fatty acids; Cardiometabolic disease risk; FISH-OIL SUPPLEMENTATION; HEART-RATE-VARIABILITY; BLOOD-PRESSURE; INSULIN-RESISTANCE; PRENATAL EXPOSURE; ADIPOSE-TISSUE; LINOLEIC-ACID; DUTCH FAMINE; PREGNANCY; PLASMA;
D O I：
10.1016/j.plefa.2015.06.001
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Background: Increasing evidence suggests that long-chain polyunsaturated fatty acid (LCPUFA) availability in utero could program later health. Objective: The objective of the study was to explore whether prenatal LCPUFA availability could be involved in programming cardiometabolic disease risk at childhood. Methods: Data of 242 mother child pairs from the Maastricht Essential Fatty Acid Birth (MEFAB) cohort were used. Multi-variable linear regression analysis was applied to identify associations between maternal LCPUFA concentrations around weeks 11, 22 and 32 of pregnancy and at time of delivery and cardiometabolic risk factors of their children (glucose metabolism, blood lipids, and blood pressure) at age 7. Results: Maternal eicosapentaenoic acid (20:5n-3) at week 11 of pregnancy was negatively associated with children's glucose (B=-0.34 mmol/L; 95% CI: -0.56, -0.12). Positive associations were found between maternal linoleic acid (18:2n-6) at time of delivery and children's proinsulin (B=0.25 pmol/L; 95% Cl: 0.08, 0.41); maternal 3-docosapentaenoic acid (22:5n-3) at week 11 and children's total cholesterol (B=1.23 mmol/L; 95% Cl: 0.45, 2.01) and low-density-lipoprotein cholesterol (B=1.12 mmol/L; 95% CI: 0.42, 1.82); and maternal osbond acid (22:5n-6) at week 22 and tetracosadienoic acid (24:2n-6) at week 32 and children's diastolic blood pressure (B=16.86 mmHg; 95% Cl: 7.63, 26.08 and B=17.75 mmHg; 95% Cl: 6.37, 29.94, respectively). Conclusion: Our findings suggest that maternal omega-6 (n-6) fatty acids may be of particular importance in relation to children's glucose metabolism and blood pressure, whereas omega-3 (n-3) fatty acids seem particularly related to blood lipids at childhood. In general, the strength of the associations appeared stronger with fatty acid concentrations in early pregnancy compared to late pregnancy. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码：21 / 27
页数：7
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