Proof-of-principle for two-stage photodynamic therapy: hypoxia triggered release of singlet oxygen

被引：46

作者：

Ayan, Seylan ^{[1
]}

Gunaydin, Gurcan ^{[2
]}

Yesilgul-Mehmetcik, Nisa ^{[3
]}

Gedik, M. Emre ^{[2
]}

Seven, Ozlem ^{[3
]}

Akkaya, Engin U. ^{[4
]}

机构：

[1] Bilkent Univ, Dept Chem, TR-06800 Ankara, Turkey

[2] Hacettepe Univ, Dept Basic Oncol, TR-06100 Ankara, Turkey

[3] Bilkent Univ, UNAM Natl Nanotechnol Res Ctr, TR-06800 Ankara, Turkey

[4] Dalian Univ Technol, State Key Lab Fine Chem, 2 Linggong Rd, Dalian 116024, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2020年 / 56卷 / 94期

关键词：

GENERATION; PROBE; PHOTOSENSITIZER;

D O I：

10.1039/d0cc06031c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We propose to overcome oxygen deficiency and light attenuation problems in photodynamic therapy (PDT), by separating photo-excitation and singlet oxygen delivery of the PDT process into two distinct operations to be carried out sequentially, at different locations. We now demonstrate the viability of this approach, using 2-pyridone derivative which yields a relatively stable endoperoxide. The initial storage endoperoxide obtained is transformed enzymatically into a more labile compound when placed in hypoxic cell cultures, and releases singlet oxygen significantly faster. The potential of this approach in advancing PDT beyond its current limits is exciting.

引用

页码：14793 / 14796

页数：4

共 25 条

[11] Activatable Photosensitizers: Agents for Selective Photodynamic Therapy [J].