Germinal Centers: Gaining Strength from the Dark Side

被引：6
作者：
Cyster, Jason G. [1 ]
机构：
[1] Univ Calif San Francisco, Howard Hughes Med Inst, Dept Microbiol & Immunol, San Francisco, CA 94143 USA
来源：
IMMUNITY | 2015年 / 43卷 / 06期
关键词：
CELL-CYCLE; DIFFERENTIATION; SELECTION; FOXO1; MYC;
D O I：
10.1016/j.immuni.2015.11.019
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Germinal center B cells exist in two conditions, a dark zone state and a light zone state. Two studies in this issue (Dominguez-Sola et al., 2015; Sander et al., 2015) report that Foxo1 deficiency causes an almost complete loss of dark zone cells and an inability to undergo robust antibody affinity maturation.
引用
收藏
页码：1026 / 1028
页数：3
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共 11 条
  • [1] Germinal-center organization and cellular dynamics
    Allen, Christopher D. C.
    Okada, Takaharu
    Cyster, Jason G.
    [J]. IMMUNITY, 2007, 27 (02) : 190 - 202
  • [2] Germinal Center Centroblasts Transition to a Centrocyte Phenotype According to a Timed Program and Depend on the Dark Zone for Effective Selection
    Bannard, Oliver
    Horton, Robert M.
    Allen, Christopher D. C.
    An, Jinping
    Nagasawa, Takashi
    Cyster, Jason G.
    [J]. IMMUNITY, 2013, 39 (05) : 912 - 924
  • [3] The cell-cycle regulator c-Myc is essential for the formation and maintenance of germinal centers
    Calado, Dinis Pedro
    Sasaki, Yoshiteru
    Godinho, Susana A.
    Pellerin, Alex
    Koechert, Karl
    Sleckman, Barry P.
    Moreno de Alboran, Ignacio
    Janz, Martin
    Rodig, Scott
    Rajewsky, Klaus
    [J]. NATURE IMMUNOLOGY, 2012, 13 (11) : 1092 - 1100
  • [4] Distinct functions for the transcription factor Foxo1 at various stages of B cell differentiation
    Dengler, Hart S.
    Baracho, Gisele V.
    Omori, Sidne A.
    Bruckner, Shane
    Arden, Karen C.
    Castrillon, Diego H.
    DePinho, Ronald A.
    Rickert, Robert C.
    [J]. NATURE IMMUNOLOGY, 2008, 9 (12) : 1388 - 1398
  • [5] The FOXO1 Transcription Factor Instructs the Germinal Center Dark Zone Program
    Dominguez-Sola, David
    Kung, Jennifer
    Holmes, Antony B.
    Wells, Victoria A.
    Mo, Tongwei
    Basso, Katia
    Dalla-Favera, Riccardo
    [J]. IMMUNITY, 2015, 43 (06) : 1064 - 1074
  • [6] The proto-oncogene MYC is required for selection in the germinal center and cyclic reentry
    Dominguez-Sola, David
    Victora, Gabriel D.
    Ying, Carol Y.
    Phan, Ryan T.
    Saito, Masumichi
    Nussenzweig, Michel C.
    Dalla-Favera, Riccardo
    [J]. NATURE IMMUNOLOGY, 2012, 13 (11) : 1083 - 1091
  • [7] T cell help controls the speed of the cell cycle in germinal center B cells
    Gitlin, Alexander D.
    Mayer, Christian T.
    Oliveira, Thiago Y.
    Shulman, Ziv
    Jones, Mathew J. K.
    Koren, Amnon
    Nussenzweig, Michel C.
    [J]. SCIENCE, 2015, 349 (6248) : 643 - 646
  • [8] Regulation of B-cell proliferation and differentiation by pre-B-cell receptor signalling
    Herzog, Sebastian
    Reth, Michael
    Jumaa, Hassan
    [J]. NATURE REVIEWS IMMUNOLOGY, 2009, 9 (03) : 195 - 205
  • [9] PI3 Kinase and FOXO1 Transcription Factor Activity Differentially Control B Cells in the Germinal Center Light and Dark Zones
    Sander, Sandrine
    Van Trung Chu
    Yasuda, Tomoharu
    Franklin, Andrew
    Graf, Robin
    Calado, Dinis Pedro
    Li, Shuang
    Imami, Koshi
    Selbach, Matthias
    Di Virgilio, Michela
    Bullinger, Lars
    Rajewsky, Klaus
    [J]. IMMUNITY, 2015, 43 (06) : 1075 - 1086
  • [10] Analysis of FOXO1 mutations in diffuse large B-cell lymphoma
    Trinh, Diane L.
    Scott, David W.
    Morin, Ryan D.
    Mendez-Lago, Maria
    An, Jianghong
    Jones, Steven J. M.
    Mungall, Andrew J.
    Zhao, Yongjun
    Schein, Jacqueline
    Steidl, Christian
    Connors, Joseph M.
    Gascoyne, Randy D.
    Marra, Marco A.
    [J]. BLOOD, 2013, 121 (18) : 3666 - 3674
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