Lewis acid deprotection of silyl-protected oligonucleotides and base-sensitive oligonucleotide analogues

被引：12

作者：

Ferreira, F ^{[1
]}

Vasseur, JJ ^{[1
]}

Morvan, F ^{[1
]}

机构：

[1] Univ Montpellier 2, CNRS, UMR 5625, Lab Chim Organ Biomol Synth, F-34095 Montpellier 5, France

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 33期

基金：

澳大利亚研究理事会;

关键词：

silyl protecting group; DNA; Teoc; Tse; Sate;

D O I：

10.1016/j.tetlet.2004.06.081

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Oligonucleotides protected with N-(trimethylsilyiethoxycarbonyl) (Teoc) and P-(trimethylsilylethanol) (Tse) groups were synthesized and deprotected by a single ZnBr2 treatment. Teoc group stabilized dA against depurination. This strategy was applied to the synthesis of base-sensitive oligonucleotide prodrugs bearing S-acetyl-2-thioethyl (Sate) phosphotriesters. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：6287 / 6290

页数：4

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