JC virus minor capsid proteins Vp2 and Vp3 are essential for virus propagation

被引：29

作者：

Gasparovic, M. L.

Gee, G. V.

Atwood, W. J.

机构：

[1] Brown Univ, Dept Biochem Mol Biol & Cell Biol, Providence, RI 02912 USA

[2] Brown Univ, Grad Program Mol Biol Cell Biol & Biochem, Providence, RI 02912 USA

[3] Brown Univ, Dept Ecol & Evolutionary Biol, Providence, RI 02912 USA

来源：

JOURNAL OF VIROLOGY | 2006年 / 80卷 / 21期

关键词：

D O I：

10.1128/JVI.01298-06

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Virus-encoded capsid proteins play a major role in the life cycles of all viruses. The JC virus capsid is composed of 72 pentamers of the major capsid protein Vp1, with one of the minor coat proteins Vp2 or Vp3 in the center of each pentamer. Vp3 is identical to two-thirds of Vp2, and these proteins share a DNA binding domain, a nuclear localization signal, and a Vp1-interacting domain. We demonstrate here that both the minor proteins and the myristylation site on Vp2 are essential for the viral life cycle, including the proper packaging of its genome.

引用

页码：10858 / 10861

页数：4

共 28 条

[1] PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY - A HITHERTO UNRECOGNIZED COMPLICATION OF CHRONIC LYMPHATIC LEUKAEMIA AND HODGKINS DISEASE
ASTROM, KE
MANCALL, EL
RICHARDSON, EP
[J]. BRAIN, 1958, 81 (01) : 93 - &
[2] INTERACTIONS AMONG THE MAJOR AND MINOR COAT PROTEINS OF POLYOMAVIRUS
BAROUCH, DH
HARRISON, SC
[J]. JOURNAL OF VIROLOGY, 1994, 68 (06) : 3982 - 3989
[3] Construction of a novel JCV/SV40 hybrid virus (JCSV) reveals a role for the JCV capsid in viral tropism
Chen, BJ
Atwood, WJ
[J]. VIROLOGY, 2002, 300 (02) : 282 - 290
[4] CLEVER J, 1993, J BIOL CHEM, V268, P20877
[5] SIMIAN-VIRUS 40 VP2/3 SMALL STRUCTURAL PROTEINS HARBOR THEIR OWN NUCLEAR TRANSPORT SIGNAL
CLEVER, J
KASAMATSU, H
[J]. VIROLOGY, 1991, 181 (01) : 78 - 90
[6] Simian virus 40 late proteins possess lytic properties that render them capable of permeabilizing cellular membranes
Daniels, Robert
Rusan, Nasser M.
Wilbuer, Anne-Kathrin
Norkin, Leonard C.
Wadsworth, Patricia
Hebert, Daniel N.
[J]. JOURNAL OF VIROLOGY, 2006, 80 (13) : 6575 - 6587
[7] Derivation of a JC virus-resistant human glial cell line: implications for the identification of host cell factors that determine viral tropism
Gee, GV
Manley, K
Atwood, WJ
[J]. VIROLOGY, 2003, 314 (01) : 101 - 109
[8] The simian virus 40 minor structural protein Vp3, but not Vp2, is essential for infectious virion formation
Gharakhanian, E
Muñoz, L
Mayorca, L
[J]. JOURNAL OF GENERAL VIROLOGY, 2003, 84 : 2111 - 2116
[9] 2 INDEPENDENT SIGNALS, A NUCLEAR-LOCALIZATION SIGNAL AND A VP1-INTERACTIVE SIGNAL, RESIDE WITHIN THE CARBOXY-35 AMINO-ACIDS OF SV40 VP3
GHARAKHANIAN, E
KASAMATSU, H
[J]. VIROLOGY, 1990, 178 (01) : 62 - 71
[10] The abundant nuclear enzyme PARP participates in the life cycle of simian virus 40 and is stimulated by minor capsid protein VP3
Gordon-Shaag, A
Yosef, Y
El-Latif, MA
Oppenheim, A
[J]. JOURNAL OF VIROLOGY, 2003, 77 (07) : 4273 - 4282

← 1 2 3 →