Production and characterization of novel neutralizing mAbs against vWF-A3 domain, an inhibitor of binding of vWF to collagen and influence of interaction between vWF and platelet GPIbα.

被引：0
|
作者：
Zhao, Yiming [1 ]
Dong, Ningzheng [1 ]
Xie, Liqjan [1 ]
Sheng, Fei [1 ]
Ruan, Changgeng [1 ]
机构：
[1] Soochow Univ, Affiliated Hosp 1, Jiangsu Inst Hematol, Suzhou, Peoples R China
来源：
BLOOD | 2006年 / 108卷 / 11期
关键词：
D O I：
10.1182/blood.V108.11.1537.1537
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
1537
引用
收藏
页码：442A / 442A
页数：1
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  • [1] An interaction between the vWF-A1 and vWF-A3 domain that may mediate vWF binding to the platelet glycoprotein GPIb/IX.
    Cruz, MA
    Connors, J
    Yuan, H
    Handin, RI
    BLOOD, 1995, 86 (10) : 268 - 268
  • [2] OPTIMAL BINDING OF VON-WILLEBRAND-FACTOR (VWF) TO COLLAGEN REQUIRES INCORPORATION OF THE VWF-A3 DOMAIN INTO FULL-LENGTH VWF
    CRUZ, MA
    LEE, JR
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    BLOOD, 1993, 82 (10) : A449 - A449
  • [3] The A3 domain of vWF regulates the binding of the A1 domain to platelet GPIb
    Obert, B
    Houllier, A
    Meyer, D
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  • [4] A novel monoclonal antibody against the extracellular domain of GPIbβ modulates vWF mediated platelet adhesion
    Perrault, C
    Moog, S
    Rubinstein, E
    Santer, M
    Baas, MJ
    de la Salle, C
    Ravanat, C
    Dambach, J
    Freund, M
    Santoso, S
    Cazenave, JP
    Lanza, F
    THROMBOSIS AND HAEMOSTASIS, 2001, 86 (05) : 1238 - 1248
  • [5] Collagen-binding mode of vWF-A3 domain determined by a transferred cross-saturation experiment
    Noritaka Nishida
    Hiromi Sumikawa
    Masayoshi Sakakura
    Nobuhisa Shimba
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  • [6] Collagen-binding mode of vWF-A3 domain determined by a transferred cross-saturation experiment
    Nishida, N
    Sumikawa, H
    Sakakura, M
    Shimba, N
    Takahashi, H
    Terasawa, H
    Suzuki, E
    Shimada, I
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  • [7] Identification of the collagen binding site in the VWF-A3 domain by molecular structure and site-specific mutagenesis.
    Cruz, MA
    Bienkowska, J
    Mato, A
    Liddington, R
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    BLOOD, 1997, 90 (10) : 88 - 88
  • [8] Interaction between A1, A2 and A3 domains regulates the binding of VWF to platelet GPIbα in solution
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  • [9] Platelet thrombus formation on collagen at high shear rate is mediated by von Willebrand factor (vWF)-GPIb interaction and may be inhibited by vWF-αIIb-β3 interaction.
    Wu, YP
    Vink, T
    Schiphorst, M
    van Zanten, GH
    Remijn, J
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  • [10] A possible role for a metal ion-dependent adhesion sequence (MIDAS) in the vWF-A3 domain in its binding to collagen.
    Cruz, MA
    Bienkowski, J
    Liddington, R
    Wise, RJ
    Handin, RI
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