Apoptosis of human pancreatic carcinoma cells induced by all-trans retinoic acid and interferon

被引：1
|
作者：
Wang, Xiao-hua [1 ]
Yin, Yuan-qin [1 ]
Ma, Ping [1 ]
Sui, Cheng-guang [1 ]
Meng, Fan-dong [1 ]
Jiang You-hong [1 ]
机构：
[1] China Med Univ, Canc Res Inst, Affiliated Hosp 1, Shenyang 110001, Peoples R China
来源：
CHINESE JOURNAL OF CANCER RESEARCH | 2009年 / 21卷 / 03期
关键词：
All-trans retinoic acid (ATRA); Interferon-alpha (IFN-alpha); Apoptosis; Human pancreatic carcinoma cells; CANCER; EXPRESSION; INHIBITION; RESISTANCE; LINES; ALPHA;
D O I：
10.1007/s11670-009-0224-3
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
To investigate the apoptosis of human pancreatic carcinoma PC3 cells induced by the combination of all-trans retinoic acid (ATRA) with interferon alpha (IFN-alpha). PC3 cells were treated with ATRA and IFN-alpha. The inhibitory rate of PC3 cell proliferation was detected using MTT method. Cellular apoptosis was determined with flow cytometry. The percentage of PC3 cell apoptosis was assayed using TUNEL methods. ATRA and IFN-alpha could inhibit cellular proliferation and induces cellular apoptosis of PC3 cells. The inhibitory effect was stronger when the ATRA and IFN-alpha were combined as a therapy. ATRA inhibits the proliferation of PC3 cells and induce the apoptosis of PC3 cells. The combination of IFN-alpha with ATRA may enhance these effects on PC3 cells.
引用
收藏
页码：224 / 228
页数：5
相关论文
共 50 条
  • [21] Decreased H expression and susceptibility to apoptosis by all-trans retinoic acid
    Cooling, L
    Hwang, D
    Shayman, JA
    TRANSFUSION, 2004, 44 (09) : 31A - 31A
  • [22] Inhibitory effect of all-trans retinoic acid on human hepatocellular carcinoma cell proliferation
    Piao, YF
    Shi, Y
    Gao, PJ
    WORLD JOURNAL OF GASTROENTEROLOGY, 2003, 9 (09) : 2117 - 2120
  • [23] All-trans retinoic acid-induced multiple mononeuropathies
    Yamaji, S
    Kanamori, H
    Mishima, A
    Fujisawa, S
    Motomura, S
    Mohri, H
    AMERICAN JOURNAL OF HEMATOLOGY, 1999, 60 (04) : 311 - 311
  • [24] ALL-TRANS RETINOIC ACID-INDUCED CARDIOVASCULAR MALFORMATIONS
    IRIE, K
    ANDO, M
    TAKAO, A
    ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1990, 588 : 387 - 388
  • [25] All-trans retinoic acid and arsenic trioxide induce apoptosis and modulate intracellular concentrations of calcium in hepatocellular carcinoma cells
    Wei, Jianfeng
    Ye, Chaoping
    Liu, Fengsheng
    Wang, Wenqing
    JOURNAL OF CHEMOTHERAPY, 2014, 26 (06) : 348 - 352
  • [26] all-trans retinoic acid enhances cisplatin-induced apoptosis in human ovarian adenocarcinoma and in squamous head and neck cancer cells
    Aebi, S
    Kroning, R
    Cenni, B
    Sharma, A
    Fink, D
    Los, G
    Weisman, R
    Howell, SB
    Christen, RD
    CLINICAL CANCER RESEARCH, 1997, 3 (11) : 2033 - 2038
  • [27] A rare case of all-trans retinoic acid induced myocarditis
    Ul Hassan, Imtiaz
    Chowdhary, Amrit
    Kidambi, Ananth
    EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING, 2021, 22 (08) : E131 - E131
  • [28] All-trans retinal, all-trans retinal and all-trans retinoic acid produce a dose dependent induction of retinoic acid 4-hydroxylase in human skin in vivo.
    Duell, EA
    Kang, SW
    Voorhees, JJ
    JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1996, 106 (04) : 138 - 138
  • [29] Granulomatous tubulointerstitial nephritis induced by all-trans retinoic acid
    Tomita, N
    Kanamori, H
    Fujita, H
    Maruta, A
    Naitoh, A
    Nakamura, S
    Ota, Y
    Nozue, N
    Kihara, M
    Ishigatsubo, Y
    ANTI-CANCER DRUGS, 2001, 12 (08) : 677 - 680
  • [30] Correlation of HSP110 expression with all-trans retinoic acid-induced apoptosis
    Evrard, L
    Vanmuylder, N
    Dourov, N
    Hermans, C
    Biermans, J
    Werry-Huet, A
    Rooze, M
    Louryan, S
    JOURNAL OF CRANIOFACIAL GENETICS AND DEVELOPMENTAL BIOLOGY, 2000, 20 (04): : 183 - 192
12345