Apoptosis of human pancreatic carcinoma cells induced by all-trans retinoic acid and interferon

被引：1
|
作者：
Wang, Xiao-hua [1 ]
Yin, Yuan-qin [1 ]
Ma, Ping [1 ]
Sui, Cheng-guang [1 ]
Meng, Fan-dong [1 ]
Jiang You-hong [1 ]
机构：
[1] China Med Univ, Canc Res Inst, Affiliated Hosp 1, Shenyang 110001, Peoples R China
来源：
CHINESE JOURNAL OF CANCER RESEARCH | 2009年 / 21卷 / 03期
关键词：
All-trans retinoic acid (ATRA); Interferon-alpha (IFN-alpha); Apoptosis; Human pancreatic carcinoma cells; CANCER; EXPRESSION; INHIBITION; RESISTANCE; LINES; ALPHA;
D O I：
10.1007/s11670-009-0224-3
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
To investigate the apoptosis of human pancreatic carcinoma PC3 cells induced by the combination of all-trans retinoic acid (ATRA) with interferon alpha (IFN-alpha). PC3 cells were treated with ATRA and IFN-alpha. The inhibitory rate of PC3 cell proliferation was detected using MTT method. Cellular apoptosis was determined with flow cytometry. The percentage of PC3 cell apoptosis was assayed using TUNEL methods. ATRA and IFN-alpha could inhibit cellular proliferation and induces cellular apoptosis of PC3 cells. The inhibitory effect was stronger when the ATRA and IFN-alpha were combined as a therapy. ATRA inhibits the proliferation of PC3 cells and induce the apoptosis of PC3 cells. The combination of IFN-alpha with ATRA may enhance these effects on PC3 cells.
引用
收藏
页码：224 / 228
页数：5
相关论文
共 50 条
  • [1] Apoptosis of Human Pancreatic Carcinoma Cells Induced By All-Trans Retinoic Acid and Interferon
    Xiao-hua Wang
    Chinese Journal of Cancer Research, 2009, 21 (03) : 224 - 228
  • [2] Differential effect of interferon-alpha on dexamethasone and all-trans retinoic acid induced apoptosis in myeloma cells.
    Liu, P
    VanNess, B
    BLOOD, 1996, 88 (10) : 388 - 388
  • [3] Downregulation of topoisomerase Ilα by all-trans retinoic acid in human cervical carcinoma cells
    Li, Xiaoting
    Fu, Shilong
    Shen, Xin
    Zhou, Donghu
    Jiang, Apei
    Han, Suping
    Feng, Qing
    CANCER RESEARCH, 2012, 72
  • [4] Proteomic analysis of apoptosis initiation induced by all-trans retinoic acid in human acute promyelocytic leukemia cells
    Wan, JH
    Wang, JL
    Cheng, HP
    Yu, YT
    Xing, GC
    Qiu, ZY
    Qian, XH
    He, FC
    ELECTROPHORESIS, 2001, 22 (14) : 3026 - 3037
  • [5] All-trans retinoic acid induces apoptosis in acute myeloblastic leukaemia cells
    A. Zheng
    E.-R. Savolainen
    P. Koistinen
    Apoptosis, 1997, 2 : 319 - 329
  • [6] All-trans retinoic acid induces apoptosis in acute myeloblastic leukaemia cells
    Zheng, A
    Savolainen, ER
    Koistinen, P
    APOPTOSIS, 1997, 2 (03) : 319 - 329
  • [7] Effects of all-trans retinoic acid (ATRA) on human myeloma cells
    Otsuki, T
    Sakaguchi, H
    Hatayama, T
    Wu, P
    Takata, A
    Hyodoh, F
    LEUKEMIA & LYMPHOMA, 2003, 44 (10) : 1651 - 1656
  • [8] Human B-cell lymphoma cell lines are highly sensitive to apoptosis induced by all-trans retinoic acid and interferon-γ
    Niitsu, N
    Higashihara, M
    Honma, Y
    LEUKEMIA RESEARCH, 2002, 26 (08) : 745 - 755
  • [9] Differential growth regulation by all-trans retinoic acid is determined by protein kinase C alpha in human pancreatic carcinoma cells
    Rosewicz, S
    Brembeck, F
    Kaiser, A
    Marschall, ZV
    Riecken, EO
    ENDOCRINOLOGY, 1996, 137 (08) : 3340 - 3347
  • [10] All-trans retinoic acid and interferon-α for treatment of human renal cell carcinoma multicellular tumor spheroids
    Rohde, D
    Brkovic, D
    d'Orville, IH
    UROLOGIA INTERNATIONALIS, 2004, 73 (01) : 47 - 53
12345