Dendritic Compartment and Neuronal Output Mode Determine Pathway-Specific Long-Term Potentiation in the Piriform Cortex

被引:34
|
作者
Johenning, Friedrich W. [1 ]
Beed, Prateep S. [1 ]
Trimbuch, Thorsten [2 ]
Bendels, Michael H. K. [1 ,3 ]
Winterer, Jochen [1 ]
Schmitz, Dietmar [1 ,4 ]
机构
[1] Charite, Neurowissensch Forschungszentrum, D-10117 Berlin, Germany
[2] Charite, Inst Cell Biol & Neurobiol, Ctr Anat, D-10117 Berlin, Germany
[3] Charite, Neurophys Grp, Dept Neurol, D-10117 Berlin, Germany
[4] Bernstein Ctr Computat Neurosci Berlin, D-10115 Berlin, Germany
来源
JOURNAL OF NEUROSCIENCE | 2009年 / 29卷 / 43期
关键词
DEPENDENT SYNAPTIC PLASTICITY; NEOCORTICAL PYRAMIDAL NEURONS; PROPAGATING ACTION-POTENTIALS; OLFACTORY CORTEX; NMDA RECEPTORS; HIPPOCAMPAL-NEURONS; APICAL DENDRITES; CRITICAL PERIOD; LEARNING RULES; CALCIUM SPIKES;
D O I
10.1523/JNEUROSCI.2672-09.2009
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The apical dendrite of layer 2/3 pyramidal cells in the piriform cortex receives two spatially distinct inputs: one projecting onto the distal apical dendrite in sensory layer 1a, the other targeting the proximal apical dendrite in layer 1b. We observe an expression gradient of A-type K+ channels that weakens the backpropagating action potential-mediated depolarization in layer 1a compared with layer 1b. We find that the pairing of presynaptic and postsynaptic firing leads to significantly smaller Ca2+ signals in the distal dendritic spines in layer 1a compared with the proximal spines in layer 1b. The consequence is a selective failure to induce long-term potentiation (LTP) in layer 1a, which can be rescued by pharmacological enhancement of action potential backpropagation. In contrast, LTP induction by pairing presynaptic and postsynaptic firing is possible in layer 1b but requires bursting of the postsynaptic cell. This output mode strongly depends on the balance of excitation and inhibition in the piriform cortex. We show, on the single-spine level, how the plasticity of functionally distinct synapses is gated by the intrinsic electrical properties of piriform cortex layer 2 pyramidal cell dendrites and the cellular output mode.
引用
收藏
页码:13649 / 13661
页数:13
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