Effect of insulin-like growth factor-1 (IGF-1) on femoral bone modeling in growing mice

被引：3

作者：

Kawata, T ^{[1
]}

Tokimasa, C ^{[1
]}

Fujita, T ^{[1
]}

Kaku, M ^{[1
]}

Tsutsui, K ^{[1
]}

Kohno, S ^{[1
]}

Matsuki, A ^{[1
]}

Tenjo, K ^{[1
]}

Ohtani, J ^{[1
]}

Motokawa, M ^{[1
]}

Kobayakawa, T ^{[1
]}

Shigekawa, M ^{[1
]}

Tanne, K ^{[1
]}

机构：

[1] Hiroshima Univ, Dept Orthodont & Craniofacial Dev Biol, Grad Sch Biomed Sci, Minami Ku, Hiroshima 7348553, Japan

来源：

EXPERIMENTAL ANIMALS | 2002年 / 51卷 / 05期

关键词：

IGF-1; long bone modeling; mouse;

D O I：

10.1538/expanim.51.521

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

The time-dependent effects of daily dosing of IGF-1 (1.21 mg/g) on the linear growth of the femur were investigated in mice. The femoral length and volume and the number of osteoclasts were significantly greater after IGF-1 injection as compared to the non-injected control, suggesting that the IGF-1 imbalance might cause a quick turnover cycle of the bone resulting in the altered femoral modeling.

引用

页码：521 / 524

页数：4

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