Pro-Resolving Lipid Mediators in the Pathophysiology of Asthma

被引：28

作者：

Kytikova, Oxana ^{[1
]}

Novgorodtseva, Tatyana ^{[1
]}

Denisenko, Yulia ^{[1
]}

Antonyuk, Marina ^{[1
]}

Gvozdenko, Tatyana ^{[1
]}

机构：

[1] Fed State Budgetary Sci Inst Far Eastern Sci Ctr, Vladivostok Branch, Inst Med Climatol & Rehabil Treatment, Russian St 73-G, Vladivostok 690105, Russia

来源：

MEDICINA-LITHUANIA | 2019年 / 55卷 / 06期

关键词：

asthma; pro-resolving lipid mediators; eicosanoids; FATTY-ACID; PRORESOLVING MEDIATORS; INCREASED EXPRESSION; PROMOTE RESOLUTION; INFLAMMATION; D1; LUNG; CELLS; E1; OMEGA-3-FATTY-ACIDS;

D O I：

10.3390/medicina55060284

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Asthma is one of the most important medical and social problems of our time due to the prevalence and the complexity of its treatment. Chronic inflammation that is characteristic of asthma is accompanied by bronchial obstruction, which involves various lipid mediators produced from n-6 and n-3 polyunsaturated fatty acids (PUFAs). The review is devoted to modern ideas about the PUFA metabolites-eicosanoids (leukotrienes, prostaglandins, thromboxanes) and specialized pro-resolving lipid mediators (SPMs) maresins, lipoxins, resolvins, protectins. The latest advances in clinical lipidomics for identifying and disclosing the mechanism of synthesis and the biological action of SPMs have been given. The current views on the peculiarities of the inflammatory reaction in asthma and the role of highly specialized metabolites of arachidonic, eicosapentaenoic and docosahexaenoic acids in this process have been described. The possibility of using SPMs as therapeutic agents aimed at controlling the resolution of inflammation in asthma is discussed.

引用

页数：12

共 72 条

[1] Aspirin-triggered resolvin D1 is produced during self-resolving gram-negative bacterial pneumonia and regulates host immune responses for the resolution of lung inflammation [J].