Chemokines in hyperthyroidism

被引：37
作者：
Ferrari, Silvia Martina [1 ]
Ruffilli, Ilaria [1 ]
Elia, Giusy [1 ]
Ragusa, Francesca [1 ]
Paparo, Sabrina Rosaria [1 ]
Patrizio, Armando [1 ]
Mazzi, Valeria [1 ]
Antonelli, Alessandro [1 ]
Fallahi, Poupak [2 ]
机构：
[1] Univ Pisa, Dept Clin & Expt Med, Pisa, Italy
[2] Univ Pisa, Dept Translat Res & New Technol Med & Surg, Pisa, Italy
来源：
JOURNAL OF CLINICAL AND TRANSLATIONAL ENDOCRINOLOGY | 2019年 / 16卷
关键词：
Chemokines; Cytokines; Hyperthyroidism; Graves' disease; CXCL10; CXCL9; ACTIVATED RECEPTOR-GAMMA; CXCL10; SERUM-LEVELS; HEPATITIS-C VIRUS; GRAVES-DISEASE; HIGH VALUES; MIXED CRYOGLOBULINEMIA; AUTOIMMUNE-THYROIDITIS; CIRCULATING CHEMOKINES; ALPHA; MODULATION;
D O I：
10.1016/j.jcte.2019.100196
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The term "hyperthyroidism" indicates a condition due to an exaggerate production of thyroid hormone; the most frequent cause is Graves' disease (GD). We review cytokines and chemokines in hyperthyroidism, with a special focus in GD. In GD, recruited Th1 lymphocytes are responsible for enhanced IFN-gamma and TNF-alpha production, which in turn stimulates Th1 chemokines release from thyrocytes, initiating and perpetuating the autoimmune process. Circulating levels of these chemokines are associated with the active phase of GD. Additional studies are necessary to investigate whether Th1 chemokines could be a novel therapeutic target in this disease.
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页数：6
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