Synthesis and characterization of a series of novel 2-Schiff base-substituted phenylpyrimidine

被引:7
作者
Liu, Manman [1 ]
Sun, Xiqing [1 ]
Zhang, Jian [1 ]
机构
[1] South Cent Univ Nationalities, Coll Chem & Mat, Wuhan 430074, Peoples R China
关键词
Biginelli; Pyrimidine; Schiff base; Synthesis; BIGINELLI DIHYDROPYRIMIDINE SYNTHESIS; IN-VITRO EVALUATION; BIOLOGICAL-ACTIVITY; TRANSFORMATION; COMPLEXES;
D O I
10.1016/j.arabjc.2014.11.053
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
A new series of pyrimidine derivatives containing Schiff bases structure have been synthesized efficiently by modification of the C-2 position of Biginelli 3,4-dihydropyrimidin-2-(1H)-thiones (DHPMs). Their structures have been characterized by IR, H-1 NMR, C-13 NMR, MS spectra and elemental analysis. (C) 2014 The Authors. Production and hosting by Elsevier B.V. on behalf of King Saud University.
引用
收藏
页码:167 / 171
页数:5
相关论文
共 27 条
[1]   Microwave assisted synthesis of novel pyrazolone derivatives attached to a pyrimidine moiety and evaluation of their anti-inflammatory, analgesic and antipyretic activities [J].
Antre, Rishikesh V. ;
Cendilkumar, A. ;
Goli, Divakar ;
Andhale, Ganesh S. ;
Oswal, Rajesh J. .
SAUDI PHARMACEUTICAL JOURNAL, 2011, 19 (04) :233-243
[2]   The tethered Biginelli condensation in natural product synthesis [J].
Aron, ZD ;
Overman, LE .
CHEMICAL COMMUNICATIONS, 2004, (03) :253-265
[3]   Antimicrobial and antitumor activity of N-heteroimmine-1,2,3-dithiazoles and their transformation in triazolo-, imidazo-, and pyrazolopirimidines [J].
Baraldi, PG ;
Pavani, MG ;
Nuñez, MD ;
Brigidi, P ;
Vitali, B ;
Gambari, R ;
Romagnoli, R .
BIOORGANIC & MEDICINAL CHEMISTRY, 2002, 10 (02) :449-456
[4]  
Biginelli P., 1893, GAZZ CHIM ITAL, V23, P360
[5]   Synthesis and in vitro microbiological evaluation of novel 4-aryl-5-isopropoxycarbonyl-6-methyl-3,4-dihydropyrimidinones [J].
Chitra, S. ;
Devanathan, D. ;
Pandiarajan, K. .
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2010, 45 (01) :367-371
[6]   Solid- and solution-phase synthesis of bioactive dihydropyrimidines [J].
Dallinger, D ;
Stadler, A ;
Kappe, CO .
PURE AND APPLIED CHEMISTRY, 2004, 76 (05) :1017-1024
[7]   Inhibition of hepatitis B virus replication by drug-induced depletion of nucleocapsids [J].
Deres, K ;
Schröder, CH ;
Paessens, A ;
Goldmann, S ;
Hacker, HJ ;
Weber, O ;
Krämer, T ;
Niewöhner, U ;
Pleiss, U ;
Stoltefuss, J ;
Graef, E ;
Koletzki, D ;
Masantschek, RNA ;
Reimann, A ;
Jaeger, R ;
Gross, R ;
Beckermann, B ;
Schlemmer, KH ;
Haebich, D ;
Rübsamen-Waigmann, H .
SCIENCE, 2003, 299 (5608) :893-896
[8]   Asymmetric organocatalytic biginelli reactions:: A new approach to quickly access optically active 3,4-Dihydropyrimidin-2-(1H)-ones [J].
Gong, Liu-Zhu ;
Chen, Xiao-Hua ;
Xu, Xiao-Ying .
CHEMISTRY-A EUROPEAN JOURNAL, 2007, 13 (32) :8920-8926
[9]  
KAPPE CO, 1993, TETRAHEDRON, V49, P6937
[10]   Biologically active dihydropyrimidones of the Biginelli-type - a literature survey [J].
Kappe, CO .
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2000, 35 (12) :1043-1052