Preparation, characterization and antibacterial effect of 2-methoxy-6-(5-H/Me/Cl/NO2-1H-benzimidazol-2-yl)phenols and some transition metal complexes

被引：26

作者：

Tavman, Aydin ^{[1
]}

Ikiz, Serkan ^{[2
]}

Bagcigil, A. Funda ^{[2
]}

Ozgur, N. Yakut ^{[2
]}

Ak, Seyyal ^{[2
]}

机构：

[1] Istanbul Univ, Fac Engn, Dept Chem, TR-34320 Istanbul, Turkey

[2] Istanbul Univ, Fac Vet, Dept Microbiol, TR-34320 Istanbul, Turkey

来源：

JOURNAL OF THE SERBIAN CHEMICAL SOCIETY | 2009年 / 74卷 / 05期

关键词：

benzimidazolylphenols; complexes; antibacterial activity; ANTIMICROBIAL ACTIVITY; STRUCTURAL-CHARACTERIZATION; IRON(III) COMPLEXES; ZINC(II); LIGANDS; NICKEL(II); COBALT(II); ION;

D O I：

10.2298/JSC0905537T

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

2-Methoxy-6-(5-H/methyl/chloro/nitro-1H-benzimidazol-2-yl)phenols (HLx; x = 1-4, respectively) ligands and HL1 complexes with Fe(NO3)(3), Cu(NO3)(2), AgNO3 and Zn(NO3)(2) were synthesized and characterized. The structures of the compounds were confirmed based on elemental analysis, molar conductivity, magnetic moment, FT-IR, H-1- and C-13-NMR. The antibacterial activity and minimum inhibitory concentration (MIC) of the free ligands, their hydrochloride salts and the complexes were evaluated using the disk diffusion method in dimethyl sulfoxide (DMSO) and the dilution method, respectively, against 9 bacteria. HL1 and HL3, as well as the Cu(II) and Zn(II) complexes, showed antibacterial activity against Gram-positive bacteria.

引用

页码：537 / 548

页数：12

共 37 条

[1] Synthesis, characterization, and antimicrobial activity of cobalt(II), nickel(II), copper(H) and zinc(II) complexes with ferrocenyl Schiff bases containing a phenol moiety
Abd-Elzaher, MM
[J]. APPLIED ORGANOMETALLIC CHEMISTRY, 2004, 18 (04) : 149 - 155
[2] Synthesis and investigation of antimicrobial activity of some bisbenzimidazole-derived chelating agents
Agh-Atabay, NM
Dulger, B
Gucin, F
[J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2003, 38 (10) : 875 - 881
[3] Comparative effects of maternal prenatal and postnatal exposures to astemizole on reproductive parameters of rats
Almeida, RG
Florio, JC
Spinosa, HS
Bernardi, MM
[J]. NEUROTOXICOLOGY AND TERATOLOGY, 2002, 24 (02) : 255 - 265
[4] [Anonymous], 2000, Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria that grow Aerobically, V5th
[5] CARDOSO EJ, 2004, ACTA TROP, V92, P237
[6] Mossbauer and electronic spectral studies of iron(III) complexes of oximes
Chandra, S
Sangeetika
Sharma, SD
[J]. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 2003, 59 (04) : 755 - 760
[7] Induction of cytochrome P450 1A1 gene expression, oxidative stress, and genotoxicity by carbaryl acid thiabendazole in transfected human HepG2 and lymphoblastoid cells
Delescluse, C
Ledirac, N
Li, RY
Piechocki, MP
Hines, RN
Gidrol, X
Rahmani, R
[J]. BIOCHEMICAL PHARMACOLOGY, 2001, 61 (04) : 399 - 407
[8] Fungal deracemization of benzoin
Demir, AS
Hamamci, H
Sesenoglu, O
Neslihanoglu, R
Asikoglu, B
Capanoglu, D
[J]. TETRAHEDRON LETTERS, 2002, 43 (36) : 6447 - 6449
[9] USE OF CONDUCTIVITY MEASUREMENTS IN ORGANIC SOLVENTS FOR CHARACTERISATION OF COORDINATION COMPOUNDS
GEARY, WJ
[J]. COORDINATION CHEMISTRY REVIEWS, 1971, 7 (01) : 81 - &
[10] Synthesis of some new benzimidazolecarboxamides and evaluation of their antimicrobial activity
Goker, H
Tuncbilek, M
Ayhan, G
Altanlar, N
[J]. FARMACO, 1998, 53 (06): : 415 - 420

← 1 2 3 4 →