Memory hierarchies map onto the hippocampal long axis in humans

被引:167
作者
Collin, Silvy H. P. [1 ]
Milivojevic, Branka [1 ]
Doeller, Christian F. [1 ]
机构
[1] Radboud Univ Nijmegen, Donders Inst Brain Cognit & Behav, NL-6525 ED Nijmegen, Netherlands
基金
欧洲研究理事会;
关键词
REPRESENTATION; DISTINCT; NEURONS;
D O I
10.1038/nn.4138
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Memories, similar to the internal representation of space, can be recalled at different resolutions ranging from detailed events to more comprehensive, multi-event narratives. Single-cell recordings in rodents have suggested that different spatial scales are represented as a gradient along the hippocampal axis. We found that a similar organization holds for human episodic memory: memory representations systematically vary in scale along the hippocampal long axis, which may enable the formation of mnemonic hierarchies.
引用
收藏
页码:1562 / 1564
页数:3
相关论文
共 20 条
[1]   The hippocampus, memory, and place cells: Is it spatial memory or a memory space? [J].
Eichenbaum, H ;
Dudchenko, P ;
Wood, E ;
Shapiro, M ;
Tanila, H .
NEURON, 1999, 23 (02) :209-226
[2]   Are the Dorsal and Ventral Hippocampus Functionally Distinct Structures? [J].
Fanselow, Michael S. ;
Dong, Hong-Wei .
NEURON, 2010, 65 (01) :7-19
[3]   Pattern Completion in Multielement Event Engrams [J].
Horner, Aidan J. ;
Burgess, Neil .
CURRENT BIOLOGY, 2014, 24 (09) :988-992
[4]  
Keefe J.O., 1978, HIPPOCAMPUS COGNITIV
[5]   Ventral Hippocampal Neurons Are Shaped by Experience to Represent Behaviorally Relevant Contexts [J].
Komorowski, Robert W. ;
Garcia, Carolyn G. ;
Wilson, Alix ;
Hattori, Shoai ;
Howard, Marc W. ;
Eichenbaum, Howard .
JOURNAL OF NEUROSCIENCE, 2013, 33 (18) :8079-8087
[6]   Robust Conjunctive Item-Place Coding by Hippocampal Neurons Parallels Learning What Happens Where [J].
Komorowski, Robert W. ;
Manns, Joseph R. ;
Eichenbaum, Howard .
JOURNAL OF NEUROSCIENCE, 2009, 29 (31) :9918-9929
[7]   Tracking the Emergence of Conceptual Knowledge during Human Decision Making [J].
Kumaran, Dharshan ;
Summerfield, Jennifer J. ;
Hassabis, Demis ;
Maguire, Eleanor A. .
NEURON, 2009, 63 (06) :889-901
[8]   Content Representation in the Human Medial Temporal Lobe [J].
Liang, Jackson C. ;
Wagner, Anthony D. ;
Preston, Alison R. .
CEREBRAL CORTEX, 2013, 23 (01) :80-96
[9]   Hippocampal Representation of Related and Opposing Memories Develop within Distinct, Hierarchically Organized Neural Schemas [J].
McKenzie, Sam ;
Frank, Andrea J. ;
Kinsky, Nathaniel R. ;
Porter, Blake ;
Riviere, Pamela D. ;
Eichenbaum, Howard .
NEURON, 2014, 83 (01) :202-215
[10]   Insight Reconfigures Hippocampal-Prefrontal Memories [J].
Milivojevic, Branka ;
Vicente-Grabovetsky, Alejandro ;
Doeller, Christian F. .
CURRENT BIOLOGY, 2015, 25 (07) :821-830