Effect of low-dose malathion on the gonadal development of adult rare minnow Gobiocypris rarus

被引：21

作者：

Zhang, Yingying ^{[1
]}

Wu, Lang ^{[1
]}

Zhang, Guo ^{[1
]}

Guan, Yongjing ^{[1
]}

Wang, Zaizhao ^{[1
]}

机构：

[1] Northwest A&F Univ, Shaanxi Key Lab Mol Biol Agr, Coll Anim Sci & Technol, Yangling 712100, Shaanxi, Peoples R China

来源：

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY | 2016年 / 125卷

基金：

中国国家自然科学基金;

关键词：

Malathion; Rare minnow Gobiocypris rarus; Sex hormone; Steroidogenic gene; Gonadal development; CLARIAS-BATRACHUS; ENDOCRINE DISRUPTION; STEROID-HORMONES; BISPHENOL-A; EXPOSURE; STEROIDOGENESIS; EXPRESSION; CATFISH; CELL; PESTICIDES;

D O I：

10.1016/j.ecoenv.2015.11.041

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Malathion is an organophosphorus pesticide that extensively used in agriculture and veterinary practices. To investigate the effects of low dose malathion on rare minnow Gobiocypris rarus gonadal development, we exposed adult rare minnow to environmentally relevant concentration malathion (2 and 20 a) for 21 days. Gonadal histology, sex hormone levels and mRNA expressions of steroidogenic genes were investigated. Malathion at both 2 and 20 mu g/L significantly up-regulated rare minnow testicular weight and promoted the progression of spermatogenesis. Neither ovarian weight nor process of ovary development was markedly changed. In testis, 2 RgiL malathion significantly down-regulated testosterone and 11-ketotestosterone levels, and up-regulated mRNA expression of steroidogenic genes. In ovaries, 2 and 20 mu g/L malathion significantly inhibited estradio117 beta levels and induced testosterone levels, both in concentration dependent manners; mRNA expressions of almost all the detected ovarian steroidogenic genes were up-regulated. The present result suggested that malathion even at low dose could pose a potential threat to adult rare minnow gonadal development. (C) 2015 Elsevier Inc. All rights reserved.

引用

页码：135 / 140

页数：6

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