Proton therapy for central nervous system tumors in children

被引：15

作者：

Ladra, Matthew M. ^{[1
]}

MacDonald, Shannon M. ^{[2
]}

Terezakis, Stephanie A. ^{[1
]}

机构：

[1] Johns Hopkins Sch Med, Dept Radiat Oncol & Mol Radiat Sci, Baltimore, MD USA

[2] Massachusetts Gen Hosp, Dept Radiat Oncol, Boston, MA 02114 USA

来源：

PEDIATRIC BLOOD & CANCER | 2018年 / 65卷 / 07期

关键词：

brain tumors; protons; radiation; CONFORMAL RADIATION-THERAPY; CLINICAL-OUTCOMES; RISK MEDULLOBLASTOMA; PEDIATRIC MEDULLOBLASTOMA; CRANIOSPINAL RADIOTHERAPY; ADJUVANT CHEMOTHERAPY; EPENDYMOMA; PATTERNS; ASSOCIATIONS; TOXICITY;

D O I：

10.1002/pbc.27046

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Proton therapy is a form of particle therapy with physical properties that provide a superior dose distribution compared to photons. The ability to spare healthy, developing tissues from low dose radiation with proton therapy is well known. The capability to decrease radiation exposure for children has been lauded as an important advance in pediatric cancer care, particularly for central nervous system (CNS) tumors. Favorable clinical outcomes have been reported and justify the increased cost and burden of this therapy. In this review, we summarize the current literature for proton therapy for pediatric CNS malignancies, with a focus on clinical outcomes to date.

引用

页数：7

共 40 条

[1]

[Anonymous], SOURC PROT THER CTR

[2] Pencil beam scanning proton therapy for pediatric intracranial ependymoma [J].

Ares, Carmen ;

Albertini, Francesca ;

Frei-Welte, Martina ;

Bolsi, Alessandra ;

Grotzer, Michael A. ;

Goitein, Gudrun ;

Weber, Damien C. .

JOURNAL OF NEURO-ONCOLOGY, 2016, 128 (01) :137-145

[3] On the benefits and risks of proton therapy in pediatric craniopharyngioma [J].

Beltran, Chris ;

Roca, Monica ;

Merchant, Thomas E. .

International Journal of Radiation Oncology Biology Physics, 2012, 82 (02)

[4] Proton Beam Therapy Versus Conformal Photon Radiation Therapy for Childhood Craniopharyngioma: Multi-institutional Analysis of Outcomes, Cyst Dynamics, and Toxicity [J].

Bishop, Andrew J. ;

Greenfield, Brad ;

Mahajan, Anita ;

Paulino, Arnold C. ;

Okcu, M. Fatih ;

Allen, Pamela K. ;

Chintagumpala, Murali ;

Kahalley, Lisa S. ;

McAleer, Mary F. ;

McGovern, Susan L. ;

Whitehead, William E. ;

Grosshans, David R. .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2014, 90 (02) :354-361

[5] DOSIMETRIC COMPARISON OF THREE-DIMENSIONAL CONFORMAL PROTON RADIOTHERAPY, INTENSITY-MODULATED PROTON THERAPY, AND INTENSITY-MODULATED RADIOTHERAPY FOR TREATMENT OF PEDIATRIC CRANIOPHARYNGIOMAS [J].

Boehling, Nicholas S. ;

Grosshans, David R. ;

Bluett, Jaques B. ;

Palmer, Matthew T. ;

Song, Xiaofei ;

Amos, Richard A. ;

Sahoo, Narayan ;

Meyer, Jeffrey J. ;

Mahajan, Anita ;

Woo, Shiao Y. .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2012, 82 (02) :643-652

[6] Proton Beam Craniospinal Irradiation Reduces Acute Toxicity for Adults With Medulloblastoma [J].

Brown, Aaron P. ;

Barney, Christian L. ;

Grosshans, David R. ;

McAleer, Mary Frances ;

de Groot, John F. ;

Puduvalli, Vinay K. ;

Tucker, Susan L. ;

Crawford, Cody N. ;

Khan, Meena ;

Khatua, Soumen ;

Gilbert, Mark R. ;

Brown, Paul D. ;

Mahajan, Anita .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2013, 86 (02) :277-284

[7] Endocrine outcomes with proton and photon radiotherapy for standard risk medulloblastoma [J].

Eaton, Bree R. ;

Esiashvili, Natia ;

Kim, Sungjin ;

Patterson, Briana ;

Weyman, Elizabeth A. ;

Thornton, Lauren T. ;

Mazewski, Claire ;

MacDonald, Tobey J. ;

Ebb, David ;

MacDonald, Shannon M. ;

Tarbell, Nancy J. ;

Yock, Torunn I. .

NEURO-ONCOLOGY, 2016, 18 (06) :881-887

[8] Clinical Outcomes Among Children With Standard-Risk Medulloblastoma Treated With Proton and Photon Radiation Therapy: A Comparison of Disease Control and Overall Survival [J].

Eaton, Bree R. ;

Esiashvili, Natia ;

Kim, Sungjin ;

Weyman, Elizabeth A. ;

Thornton, Lauren T. ;

Mazewski, Claire ;

MacDonald, Tobey ;

Ebb, David ;

MacDonald, Shannon M. ;

Tarbell, Nancy J. ;

Yock, Torunn I. .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2016, 94 (01) :133-138

[9] Risk-adapted craniospinal radiotherapy followed by high-dose chemotherapy and stem-cell rescue in children with newly diagnosed medulloblastoma (St Jude Medulloblastoma-96): long-term results from a prospective, multicentre trial [J].

Gajjar, Amar ;

Chintagumpala, Murali ;

Ashley, David ;

Kellie, Stewart ;

Kun, Larry E. ;

Merchant, Thomas E. ;

Woo, Shaio ;

Wheeler, Greg ;

Ahern, Valerie ;

Krasin, Matthew J. ;

Fouladi, Maryam ;

Broniscer, Alberto ;

Krance, Robert ;

Hale, Gregory A. ;

Stewart, Clinton F. ;

Dauser, Robert ;

Sanford, Robert A. ;

Fuller, Christine ;

Lau, Ching ;

Boyett, James M. ;

Wallace, Dana ;

Gilbertson, Richard J. .

LANCET ONCOLOGY, 2006, 7 (10) :813-820

[10] Incidence of CNS Injury for a Cohort of 111 Patients Treated With Proton Therapy for Medulloblastoma: LET and RBE Associations for Areas of Injury [J].

Giantsoudi, Drosoula ;

Sethi, Roshan V. ;

Yeap, Beow Y. ;

Eaton, Bree R. ;

Ebb, David H. ;

Caruso, Paul A. ;

Rapalino, Otto ;

Chen, Yen-Lin E. ;

Adams, Judith A. ;

Yock, Torunn I. ;

Tarbell, Nancy J. ;

Paganetti, Harald ;

MacDonald, Shannon M. .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2016, 95 (01) :287-296

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