apM1 gene rs266729 C>G polymorphism and ischemic stroke susceptibility: a meta-analysis base on 7 case-control studies

Objective: The goal of this study was to investigate the relationship between the adiponectin (apM1) gene rs266729 locus C>G polymorphism and ischemic stroke susceptibility by meta-analysis. Methods: The electronic databases of Pubmed, EM Base, Web of Science, Google scholar, CBM and CNKI were systematic searched with the text words of "stroke", "apM1 gene", "ADIPOQ", "ACDC" "GBP 28" "Acrp30" and "polymorphism". The relationship between apM1 gene rs266729 locus C>G polymorphism and ischemic stroke susceptibility was demonstrated by odds ratio (OR) and corresponding 95% confidence interval (95% CI). Data was pooled by random or fixed effect model according to the heterogeneity evaluation across the included studies. Publication bias was evaluated by Begg's funnel plot and Egger's line regression test. All the data was analyzed by ReviewMan 5.1 and Stata10.0 SE software. Results: Seven case-control studies were included in the meta-analysis. The relationship between apM1 gene rs266729 locus C>G polymorphism and ischemic stroke susceptibility was evaluated separated through the hypothesis of dominant (GG+CG vs CC), recessive (GG vs CC+CG) and homologous (GG vvs CC) genetic model. In a dominant genetic model, the combined OR = 1.20 (95% CI: 1.08 similar to 1.34) by fixed effect model. For a recessive genetic model, the OR was pooled by random effect model with point estimated of 1.26 and its 95% confidence interval of 0.78 similar to 2.05. In the aspect of homologous genetic model, the OR = 1.35 (95% CI: 0.82 similar to 2.22), through random effect model because of significant publication bias among the included studies. Conclusion: In the condition of dominant genetic model, people carrying G allele may have increased risk of developing ischemic stroke.