Race, Ancestry, and Vitamin D Metabolism:The Multi-Ethnic Study of Atherosclerosis

被引：50

作者：

Hsu, Simon ^{[1
]}

Hoofnagle, Andrew N. ^{[2
]}

Gupta, Deepak K. ^{[3
,4
]}

Gutierrez, Orlando M. ^{[5
,6
]}

Peralta, Carmen A. ^{[7
,8
,9
]}

Shea, Steven ^{[10
,11
]}

Allen, Norrina B. ^{[12
]}

Burke, Gregory ^{[13
]}

Michos, Erin D. ^{[14
,15
,16
]}

Ix, Joachim H. ^{[17
,18
]}

Siscovick, David ^{[19
]}

Psaty, Bruce M. ^{[20
,21
,22
,23
]}

Watson, Karol E. ^{[24
]}

Kestenbaum, Bryan ^{[1
]}

de Boer, Ian H. ^{[1
]}

Robinson-Cohen, Cassianne ^{[25
,26
]}

机构：

[1] Univ Washington, Kidney Res Inst, Div Nephrol, Dept Med, Seattle, WA 98104 USA

[2] Univ Washington, Dept Lab Med, Seattle, WA 98195 USA

[3] Vanderbilt Univ, Med Ctr, Vanderbilt Translat & Clin Cardiovasc Res Ctr, Nashville, TN 37203 USA

[4] Vanderbilt Univ, Med Ctr, Dept Med, Div Cardiovasc Med, Nashville, TN 37232 USA

[5] Univ Alabama Birmingham, Dept Med, Div Nephrol, Birmingham, AL 35294 USA

[6] Univ Alabama Birmingham, Dept Epidemiol, Birmingham, AL 35294 USA

[7] Cricket Hlth Inc, San Francisco, CA 94108 USA

[8] Kidney Hlth Res Collaborat, San Francisco, CA 94121 USA

[9] Univ Calif San Francisco, San Francisco, CA 94143 USA

[10] Columbia Univ Coll Phys & Surg, Dept Med, New York, NY 10032 USA

[11] Columbia Univ, Mailman Sch Publ Hlth, Dept Epidemiol, New York, NY 10032 USA

[12] Northwestern Univ, Dept Internal Med, Chicago, IL 60611 USA

[13] Wake Forest Sch Med, Div Publ Hlth Sci, Winston Salem, NC 27101 USA

[14] Johns Hopkins Univ, Dept Med, Div Cardiol, Baltimore, MD 21287 USA

[15] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD 21205 USA

[16] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Welch Ctr Prevent Epidemiol & Clin Res, Baltimore, MD 21205 USA

[17] Vet Affairs San Diego Healthcare Syst, Nephrol Sect, San Diego, CA USA

[18] Univ Calif San Diego, Div Nephrol Hypertens, San Diego, CA 92093 USA

[19] New York Acad Med, New York, NY 10029 USA

[20] Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA 98195 USA

[21] Univ Washington, Dept Epidemiol, Cardiovasc Hlth Res Unit, Seattle, WA 98195 USA

[22] Univ Washington, Dept Hlth Serv, Cardiovasc Hlth Res Unit, Seattle, WA 98195 USA

[23] Kaiser Permanente Washington Hlth Res Inst, Seattle, WA 98101 USA

[24] UCLA, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA

[25] Vanderbilt Univ, Dept Med, Med Ctr, Div Nephrol & Hypertens, Nashville, TN 37232 USA

[26] Vanderbilt Univ, Vanderbilt Ctr Kidney Dis, Med Ctr, Nashville, TN 37232 USA

来源：

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM | 2020年 / 105卷 / 12期

关键词：

vitamin D; mineral metabolism; parathyroid hormone; ancestry; race; SERUM 25-HYDROXYVITAMIN D; BONE-MINERAL DENSITY; D-BINDING PROTEIN; FIBROBLAST GROWTH FACTOR-23; CHRONIC KIDNEY-DISEASE; 3RD NATIONAL-HEALTH; PARATHYROID-HORMONE; RACIAL-DIFFERENCES; SECONDARY HYPERPARATHYROIDISM; ANNULAR CALCIFICATION;

D O I：

10.1210/clinem/dgaa612

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Context: A comprehensive characterization of racial/ethnic variations in vitamin D metabolism markers may improve our understanding of differences in bone and mineral homeostasis and the risk of vitamin D-related diseases. Objective: Describe racial/ethnic differences in vitamin D metabolism markers and their associations with genetic ancestry. Design, Setting, Participants: In a cross-sectional study within the Multi-Ethnic Study of Atherosclerosis (MESA), we compared a comprehensive panel of vitamin D metabolism markers across self-reported racial/ethnic groups of Black (N = 1759), White (N = 2507), Chinese (N = 788), and Hispanic (N = 1411). We evaluated associations of proportion African and European ancestry with this panel of markers in Black and Hispanic participants using ancestry informative markers. Latent class analysis evaluated associations between patterns of vitamin D measurements with race/ethnicity. Results: Compared with Black participants, White participants had significantly higher serum concentrations of 25-hydroxyvitamin D and fibroblast growth factor-23; lower concentrations of parathyroid hormone and 1,25-dihydroxyvitamin D; circulating vitamin D metabolite ratios suggesting lower CYP27B1 and higher CYP24A1 activity; higher urinary concentrations of calcium and phosphorus with higher urinary fractional excretion of phosphorus; and differences in vitamin D binding globulin haplotypes. Higher percent European ancestry was associated with higher 25-hydroxyvitamin D and lower parathyroid hormone concentrations among Black and Hispanic participants. Latent classes defined by vitamin D measurements reflected these patterns and differed significantly by race/ethnicity and ancestry. Conclusions: Markers of vitamin D metabolism vary significantly by race/ethnicity, may serve to maintain bone and mineral homeostasis across ranges of 25-hydroxyvita min D production, and be attributable, at least partly, to genetic ancestry.

引用

页数：14

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