Dietary habits in adult Japanese patients with atopic dermatitis

被引：13

作者：

Ito, Michiko ^{[1
]}

Morita, Takashi ^{[2
]}

Okazaki, Shizuka ^{[2
]}

Koto, Mototaka ^{[2
]}

Ichikawa, Yuri ^{[2
]}

Takayama, Ryoko ^{[1
]}

Hoashi, Toshihiko ^{[1
]}

Saeki, Hidehisa ^{[1
]}

Kanda, Naoko ^{[2
]}

机构：

[1] Nippon Med Sch, Dept Dermatol, Tokyo, Japan

[2] Chiba Hokusoh Hosp, Nippon Med Sch, Dept Dermatol, 1715 Kamagari, Inzai, Chiba 2701694, Japan

来源：

JOURNAL OF DERMATOLOGY | 2019年 / 46卷 / 06期

基金：

日本学术振兴会;

关键词：

alcohol; atopic dermatitis; brief-type self-administered diet history questionnaire; n-6 polyunsaturated fatty acid; vitamin B-6; RISK-FACTORS; FATTY-ACIDS; HISTORY QUESTIONNAIRES; BARRIER FUNCTION; FOOD; ECZEMA; AQUAPORIN-3; EXPRESSION; GUIDELINES; CYTOKINES;

D O I：

10.1111/1346-8138.14881

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Dietary habits can modulate the pathogenesis of atopic dermatitis. We evaluated these habits in adult Japanese patients with atopic dermatitis using a validated, brief-type self-administered diet history questionnaire and compared the results to those of age- and sex-matched healthy controls. Patients with atopic dermatitis showed higher intakes of carbohydrate and potatoes and lower intakes of alcohol, niacin, meat and oils/fats compared with those of the healthy controls. The results of logistic regression analysis showed that the intake of alcohol was negatively associated with atopic dermatitis (odds ratio, 0.905; 95% confidence interval, 0.832-0.983; P = 0.0181). The intakes of vitamin B-6 and fruit were positively correlated with the severity scoring of atopic dermatitis. Multiple regression analysis revealed that vitamin B-6 intake was a predictor of the severity scoring of atopic dermatitis (beta = 26.98508709, t = 2.3995292, P = 0.01933781). The intakes of vegetable fat, n-6 polyunsaturated fatty acid, and confections were lower in the severe atopic dermatitis group (severity scoring of atopic dermatitis, >= 33) than those in the mild group. Atopic dermatitis is negatively associated with alcohol intake, and intake of vitamin B-6 is a predictor of severity scoring of atopic dermatitis. The intake of n-6 polyunsaturated fatty acid is lower in the severe atopic dermatitis group than that in the mild group. Further study is warranted on the relationships of these results with abnormal immune responses, impaired skin barrier or pruritus in atopic dermatitis.

引用

页码：515 / 521

页数：7

共 33 条

[1] Dihomo-γ-linolenic acid prevents the development of atopic dermatitis through prostaglandin D1 production in NC/Tnd mice [J].