Transcranial sonography of the substantia nigra and MIBG myocardial scintigraphy: Complementary role in the diagnosis of Parkinson's disease

被引：10

作者：

Kajimoto, Yoshinori ^{[1
]}

Miwa, Hideto ^{[1
]}

Okawa-Izawa, Masae ^{[1
]}

Hironishi, Masaya ^{[1
]}

Kondo, Tomoyoshi ^{[1
]}

机构：

[1] Wakayama Med Univ, Dept Neurol, Wakayama 6418510, Japan

来源：

PARKINSONISM & RELATED DISORDERS | 2009年 / 15卷 / 04期

关键词：

Parkinson's disease; Transcranial sonography; MIBG myocardial scintigraphy; Substantia nigra; CARDIAC SYMPATHETIC DENERVATION; SLEEP BEHAVIOR DISORDER; JAPANESE PATIENTS; PROGRESSION; HYPERECHOGENICITY; ECHOGENICITY; DYSFUNCTION; ULTRASOUND; RELATIVES; GANGLIA;

D O I：

10.1016/j.parkreldis.2008.06.004

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Both transcranial sonography (TCS) of the substantia nigra (SN) and metaiodobenzylguanidine (MIBG) myocardial scintigraphy have been determined to be useful for the diagnosis of Parkinson's disease (PD). In the present study, we performed both tests in 65 consecutive Japanese patients with idiopathic PD. In 30 PD patients (46.2%), the midbrain was adequately displayed by TCS allowing quantitative measurements of SN hyperechogenic areas. No significant correlation was found between the area of SN echogenicity and the reduction of myocardial uptake of MIBG. However, if the cut-off value was appropriately set, 29 patients (97%) were identified as abnormal by combined TCS and MIBG myocardial scintigraphy. Since TCS and MIBG myocardial scintigraphy can distinctively detect PD-related pathological phenomenon, it is expected that the combination of these tests could contribute to an accurate diagnosis of PD. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：270 / 272

页数：3

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