Catecholaminergic control of NK cell cytolytic activity regulatory factors in the spleen

被引：33

作者：

Dokur, M

Boyadjieva, N

Sarkar, DK

机构：

[1] Rutgers State Univ, Endocrinol Program, Div Biomed, Ctr Alcohol Studies, New Brunswick, NJ 08901 USA

[2] Rutgers State Univ, Dept Anim Sci, New Brunswick, NJ 08901 USA

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2004年 / 151卷 / 1-2期

关键词：

granzyme B; perform; IFN-gamma; splenocytes; real-time RT-PCR; beta-adrenergic agonist;

D O I：

10.1016/j.jneuroim.2004.03.003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We examined the effects of norepinephrine (NE), isoproterenot (ISO) and metaproterenol (MP) on natural killer (NK) cell cytolytic activity and on the protein and mRNA levels of the regulatory factors perform and granzyme B and interferon-gamma (IFN-gamma) in splenocytes. NE, the beta-adrenergic agonist ISO, and the beta2-selective-agonist NIP all inhibited the protein and mRNA levels of perform, granzyme B and mRNA levels of IFN-gamma. NE inhibited NK cell cytolytic activity as well. Furthermore, MP inhibition of granzyme B mRNA was blocked by the beta-antagonist nadolol. These data suggest that NE and beta-adrenergic agonists may inhibit NK cell cytolytic activity by regulating the production of perform, granzyme B, and IFN-gamma in splenocytes. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：148 / 157

页数：10

共 62 条

[1] In vivo regulation of murine granzyme B gene transcription in activated primary T cells [J].