IL-17 and IL-22 in colitis associated colorectal cancer in mice

被引：0

作者：

Yuksel, Elif Saritas ^{[1
]}

Topa, Firdevs ^{[1
]}

Gur, Ozlem ^{[2
]}

Topal, Fatih ^{[1
]}

Karahanli, Cengiz ^{[1
]}

Uran, Berna ^{[2
]}

机构：

[1] Izmir Katip Celebi Univ, Gastroenterol Dept, Izmir, Turkey

[2] Izmir Katip Celebi Univ, Surg Dept, Izmir, Turkey

来源：

MEDICAL SCIENCE | 2019年 / 23卷 / 97期

关键词：

INNATE LYMPHOID-CELLS; INTERLEUKIN-22; ACTIVATION; TUMORIGENESIS; STAT3;

D O I：

暂无

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Evidence from animal models suggests that innate lymphoid cells (ILC) and especially IL23 responsive ILC3 may contribute to intestinal carcinogenesis. IL-17 and IL-22 are two major cytokins released from ILC. We have investigated mechanisms responsible for tumour-causing inflammation in a mouse model, which, like human colorectal cancer, exhibits upregulation of IL-22 and IL-17. Our results suggest that the innate immune system participates to gut inflammation and colorectal cancer, suggesting that inflammatory responses can be common to both pathologies and contribute to the development of chronic inflammation associated cancer.

引用

页码：375 / 380

页数：6

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