Releasing the brakes: a case report of pulmonary arterial hypertension induced by immune checkpoint inhibitor therapy

被引：13

作者：

Glick, Matthew ^{[1
]}

Baxter, Chase ^{[1
]}

Lopez, David ^{[1
]}

Mufti, Kashif ^{[2
]}

Sawada, Stephen ^{[3
]}

Lahm, Tim ^{[4
,5
]}

机构：

[1] Indiana Univ Sch Med, Dept Med, Internal Med Residency Program, Indianapolis, IN 46202 USA

[2] Indiana Univ Sch Med, Dept Med, Div Rheumatol, Indianapolis, IN 46202 USA

[3] Indiana Univ Sch Med, Krannert Inst Cardiol, Dept Med, Indianapolis, IN 46202 USA

[4] Indiana Univ Sch Med, Div Pulm Crit Care Sleep & Occupat Med, Dept Med, Indianapolis, IN 46202 USA

[5] Richard L Roudebush VA Med Ctr, Indianapolis, IN USA

来源：

PULMONARY CIRCULATION | 2020年 / 10卷 / 04期

关键词：

autoimmune disease; durvalumab; immunotherapy; programmed death-ligand 1 inhibitor; right heart failure;

D O I：

10.1177/2045894020960967

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Immune checkpoint inhibitors successfully treat various malignancies by inducing an immune response to tumor cells. However, their use has been associated with a variety of autoimmune disorders, such as diabetes, hepatitis, and pneumonitis. Pulmonary arterial hypertension due to checkpoint inhibitor use has not yet been described. We present a novel case of pulmonary arterial hypertension associated with systemic lupus erythematosus and Sjogren's syndrome overlap that was induced by therapy with the checkpoint inhibitor durvalumab.

引用

页数：4

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