The cholesterol mobilizing transporter ABCA1 as a new therapeutic target for cardiovascular disease

被引：19
作者：
Oram, JF [1 ]
机构：
[1] Univ Washington, Dept Med, Seattle, WA 98195 USA
来源：
TRENDS IN CARDIOVASCULAR MEDICINE | 2002年 / 12卷 / 04期
关键词：
D O I：
10.1016/S1050-1738(02)00159-7
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Atherosclerotic cardiovascular disease remains the leading cause of morbidity and mortality in Western societies. A hallmark of the developing atherosclerotic lesion is the appearance of cholesterol-laden macrophages in the artery wall. A cell membrane transporter called ABCA1 mediates the removal of excess cholesterol from macrophages into the lipoprotein pathway. This makes ABCA1 target for reducing cholesterol cholesterol deposit in tissues eliminating excess cholestrol from the body, and preventing cardiovascular disease. (C) 2002, Elsevier Science Inc.
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收藏
页码：170 / 175
页数：6
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