Enhancing anticancer cytotoxicity through bimodal drug delivery from ultrasmall Zr MOF nanoparticles

被引：93

作者：

Lazaro, Isabel Abanades ^{[1
]}

Lazaro, Sandra Abanades ^{[1
]}

Forgan, Ross S. ^{[1
]}

机构：

[1] Univ Glasgow, Sch Chem, WestCHEM, Univ Ave, Glasgow G12 8QQ, Lanark, Scotland

来源：

CHEMICAL COMMUNICATIONS | 2018年 / 54卷 / 22期

关键词：

METAL-ORGANIC FRAMEWORKS; COLLOIDAL STABILITY; DICHLOROACETATE; DESIGN; ENDOCYTOSIS; CHEMISTRY; CANCER; TUMOR;

D O I：

10.1039/c7cc09739e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Dual delivery of dichloroacetate and 5-fluorouracil from Zr MOFs into cancer cells is found to enhance in vitro cytotoxicity. Tuning particle size and, more significantly, surface chemistry, further improves cytotoxicity by promoting caveolae-mediated endocytosis and cytosolic cargo delivery.

引用

页码：2792 / 2795

页数：4

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