Enhancing anticancer cytotoxicity through bimodal drug delivery from ultrasmall Zr MOF nanoparticles

被引：93
作者：
Lazaro, Isabel Abanades [1 ]
Lazaro, Sandra Abanades [1 ]
Forgan, Ross S. [1 ]
机构：
[1] Univ Glasgow, Sch Chem, WestCHEM, Univ Ave, Glasgow G12 8QQ, Lanark, Scotland
来源：
CHEMICAL COMMUNICATIONS | 2018年 / 54卷 / 22期
关键词：
METAL-ORGANIC FRAMEWORKS; COLLOIDAL STABILITY; DICHLOROACETATE; DESIGN; ENDOCYTOSIS; CHEMISTRY; CANCER; TUMOR;
D O I：
10.1039/c7cc09739e
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Dual delivery of dichloroacetate and 5-fluorouracil from Zr MOFs into cancer cells is found to enhance in vitro cytotoxicity. Tuning particle size and, more significantly, surface chemistry, further improves cytotoxicity by promoting caveolae-mediated endocytosis and cytosolic cargo delivery.
引用
收藏
页码：2792 / 2795
页数：4
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