Experimental determination and correlation of artemisinin's solubility in supercritical carbon dioxide

被引:38
作者
Coimbra, Patricia
Blanco, Miguel R.
Silva, Helio S. R. Costa
Gil, Maria H.
de Sousa, Herminio C.
机构
[1] Univ Coimbra, Fac Ciencias & Tecnol, Dept Engn Quim, P-3030290 Coimbra, Portugal
[2] Univ Sao Paulo, Fac Ciencias Farmaceut, BR-05508900 Sao Paulo, Brazil
关键词
D O I
10.1021/je060015y
中图分类号
O414.1 [热力学];
学科分类号
摘要
The measurement and correlation of the experimental solubility of the antimalarial artemisinin ( Artemisia annua L.) in supercritical carbon dioxide is reported. Results were obtained using a static analytical method at 308.2, 318.2, and 328.2 K, and in a pressure range from 10.0 up to 25.0 MPa. Solubility experimental data were correlated with three density-based models (Chrastil, Bartle, and Mendez-Santiago-Teja models) and with two cubic equation of state (EOS) models, namely, the Peng-Robinson EOS and the Soave-Redlich-Kwong EOS, together with the conventional van der Waals mixing and combining rules. Good correlation results were obtained between the calculated and the experimental solubility to all fitted models. Results clearly show the feasibility of processing this antimalarial drug using supercritical fluid technologies and processes.
引用
收藏
页码:1097 / 1104
页数:8
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