Incidence and transmission patterns of tuberculosis among indigenous populations in Brazil

被引：15

作者：

Cunha, Eunice Atsuko ^{[1
]}

Ferrazoli, Lucilaine ^{[2
]}

Riley, Lee W. ^{[3
]}

Basta, Paulo Cesar ^{[4
]}

Honer, Michael Robert ^{[5
]}

Maia, Rosalia ^{[6
]}

da Costa, Izaias Pereira ^{[7
]}

机构：

[1] Lab Cent Saude Publ Mato Grosso do Sul, Secao Micobacteriol, Campo Grande, MS, Brazil

[2] Adolfo Lutz Inst, Nucleo TB & Micobacteriose, Sao Paulo, Brazil

[3] Univ Calif Berkeley, Sch Publ Hlth, Div Infect Dis & Vaccinol, Berkeley, CA 94720 USA

[4] Fiocruz MS, Escola Nacl Saude Publ, Rio De Janeiro, RJ, Brazil

[5] Univ Catolica Dom Bosco, Campo Grande, MS, Brazil

[6] Minist Saude, Programa Nacl Controle TB, Brasilia, DF, Brazil

[7] Univ Fed Mato Grosso do Sul, Fac Med, Campo Grande, MS, Brazil

来源：

MEMORIAS DO INSTITUTO OSWALDO CRUZ | 2014年 / 109卷 / 01期

关键词：

tuberculosis; genotyping; microbiology; molecular epidemiology; South American indigenous people; MYCOBACTERIUM-TUBERCULOSIS; MOLECULAR EPIDEMIOLOGY; PERFORMANCE; COMMUNITY; DIAGNOSIS; STRAINS; AMAZON; TOOL;

D O I：

10.1590/0074-0276130082

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Approximately 10% of the Brazilian indigenous population lives in the state of Mato Grosso do Sul (MS), where a large number of new cases of tuberculosis (TB) are reported. This study was conducted to assess TB occurrence, transmission and the utility of TB diagnosis based on the Ogawa-Kudoh (O-K) culture method in this remote population. The incidence of TB was estimated by a retrospective review of the surveillance data maintained by the Notifiable Diseases Surveillance System for the study region. The TB transmission pattern among indigenous people was assessed by genotyping Mycobacterium tuberculosis isolates using the IS6110 restriction fragment length polymorphism (RFLP) technique. Of the 3,093 cases identified from 1999-2001, 610 (similar to 20%) were indigenous patients (average incidence: 377/100,000/year). The use of the O-K culture method increased the number of diagnosed cases by 34.1%. Of the genotyped isolates from 52 indigenous patients, 33 (63.5%) belonged to cluster RFLP patterns, indicating recently transmitted TB. These results demonstrate high, on-going TB transmission rates among the indigenous people of MS and indicate that new efforts are needed to disrupt these current transmissions.

引用

页码：108 / 113

页数：6