Liquid biopsies come of age: towards implementation of circulating tumour DNA

被引：1856

作者：

Wan, Jonathan C. M. ^{[1
,2
]}

Massie, Charles ^{[1
,2
]}

Garcia-Corbacho, Javier ^{[1
,3
]}

Mouliere, Florent ^{[1
,2
]}

Brenton, James D. ^{[1
,2
]}

Caldas, Carlos ^{[1
,2
,4
]}

Pacey, Simon ^{[2
,4
]}

Baird, Richard ^{[2
,4
]}

Rosenfeld, Nitzan ^{[1
,2
]}

机构：

[1] Cancer Res UK Cambridge Inst, Li Ka Shing Ctr, Robinson Way, Cambridge CB2 0RE, England

[2] Canc Res UK Cambridge Ctr, Cambridge CB2 0RE, England

[3] Hosp Clin Barcelona, IDIBAPs, Clin Inst Haematol & Oncol Dis, Clin Trials Unit, Carrer Villarroel 170, E-08036 Barcelona, Spain

[4] Univ Cambridge, Dept Oncol, Hutchison MRC Res Ctr, Box 197,Cambridge Biomed Campus, Cambridge CB2 0XZ, England

来源：

NATURE REVIEWS CANCER | 2017年 / 17卷 / 04期

基金：

欧洲研究理事会;

关键词：

CELL-FREE DNA; COLORECTAL-CANCER PATIENTS; PRIMARY BREAST-CANCER; FACTOR RECEPTOR MUTATIONS; COPY NUMBER ABERRATIONS; FREE NUCLEIC-ACIDS; BARR-VIRUS DNA; LUNG-CANCER; PLASMA DNA; ACQUIRED-RESISTANCE;

D O I：

10.1038/nrc.2017.7

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Improvements in genomic and molecular methods are expanding the range of potential applications for circulating tumour DNA (ctDNA), both in a research setting and as a `liquid biopsy' for cancer management. Proof-of-principle studies have demonstrated the translational potential of ctDNA for prognostication, molecular profiling and monitoring. The field is now in an exciting transitional period in which ctDNA analysis is beginning to be applied clinically, although there is still much to learn about the biology of cell-free DNA. This is an opportune time to appraise potential approaches to ctDNA analysis, and to consider their applications in personalized oncology and in cancer research.

引用

页码：223 / 238

页数：16

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