Neurotransmitter receptor/G-protein mediated signal transduction in Alzheimer's disease brain

被引：14
|
作者：
Cowburn, RF
Fowler, CJ
ONeill, C
机构：
[1] UMEA UNIV, DEPT PHARMACOL, S-90187 UMEA, SWEDEN
[2] NATL UNIV IRELAND UNIV COLL CORK, DEPT BIOCHEM, CORK, IRELAND
来源：
NEURODEGENERATION | 1996年 / 5卷 / 04期
关键词：
adenylyl cyclase; Alzheimer's disease; beta-amyloid; G-protein; phospholipase C; protein kinase C; neurotransmission;
D O I：
10.1006/neur.1996.0067
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Recent evidence suggests that the neurochemical pathology of Alzheimer's disease includes severe disruptions of the neurotransmitter receptor/G-protein mediated phosphatidylinositol hydrolysis and adenylyl cyclase signal transduction pathways. The present article briefly reviews evidence from postmortem studies describing disruptions to these systems and speculates as to the importance of these changes in terms of contributing to disease pathology and limiting the success of neurotransmitter replacement strategies. (C) 1996 Academic Press Limited
引用
收藏
页码：483 / 488
页数：6
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