Epigenetics: linking social and environmental exposures to preterm birth

被引:49
作者
Burris, Heather H. [1 ,2 ]
Baccarelli, Andrea A. [2 ]
Wright, Robert O. [3 ,4 ]
Wright, Rosalind J. [4 ,5 ]
机构
[1] Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Dept Neonatol, Boston, MA 02215 USA
[2] Harvard Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA 02115 USA
[3] Icahn Sch Med Mt Sinai, Dept Prevent Med, New York, NY 10029 USA
[4] Icahn Sch Med Mt Sinai, Mindich Child Hlth & Dev Inst, New York, NY 10029 USA
[5] Icahn Sch Med Mt Sinai, Dept Pediat, Kravis Childrens Hosp, New York, NY 10029 USA
基金
美国国家卫生研究院;
关键词
FOR-GESTATIONAL-AGE; PHTHALATE EXPOSURE; DNA METHYLATION; DEVELOPMENTAL ORIGINS; PREGNANT-WOMEN; BISPHENOL-A; HEALTH; POPULATION; DISPARITIES; MOTHER;
D O I
10.1038/pr.2015.191
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Preterm birth remains a leading cause of infant mortality and morbidity. Despite decades of research, marked racial and socioeconomic disparities in preterm birth persist. In the Unites States, more than 16% of African-American infants are born before 37 wk of gestation compared with less than 11% of white infants. While income and education differences predict a portion of these racial disparities, income and education are proxies of the underlying causes rather than the true cause. How these differences lead to the pathophysiology remains unknown. Beyond tobacco smoke exposure, most preterm birth investigators overlook environment exposures that often correlate with poverty. Environmental exposures to industrial contaminants track along both socioeconomic and racial/ethnic lines due to cultural variation in personal product use, diet, and residential geographical separation. Emerging evidence suggests that environmental exposure to metals and plasticizers contribute to preterm birth and epigenetic modifications. The extent to which disparities in preterm birth result from interactions between the social and physical environments that produce epigenetic modifications remains unclear. In this review, we highlight studies that report associations between environmental exposures and preterm birth as well as perinatal epigenetic sensitivity to environmental contaminants and socioeconomic stressors.
引用
收藏
页码:136 / 140
页数:5
相关论文
共 44 条
[1]   The developmental origins of chronic adult disease [J].
Barker, DJP .
ACTA PAEDIATRICA, 2004, 93 :26-33
[2]  
[Behrman R.E. Institute of Medicine (US) Institute of Medicine (US)], 2007, Committee on understanding premature birth and assuring healthy outcomes
[3]   Phthalate exposure among pregnant women in Jerusalem, Israel: Results of a pilot study [J].
Berman, Tamar ;
Hochner-Celnikier, Drorit ;
Calafat, Antonia M. ;
Needham, Larry L. ;
Amitai, Yona ;
Wormser, Uri ;
Richter, Elihu .
ENVIRONMENT INTERNATIONAL, 2009, 35 (02) :353-357
[4]   National, regional, and worldwide estimates of preterm birth rates in the year 2010 with time trends since 1990 for selected countries: a systematic analysis and implications [J].
Blencowe, Hannah ;
Cousens, Simon ;
Oestergaard, Mikkel Z. ;
Chou, Doris ;
Moller, Ann-Beth ;
Narwal, Rajesh ;
Adler, Alma ;
Garcia, Claudia Vera ;
Rohde, Sarah ;
Say, Lale ;
Lawn, Joy E. .
LANCET, 2012, 379 (9832) :2162-2172
[5]   Phthalate exposure and children's health [J].
Braun, Joseph M. ;
Sathyanarayana, Sheela ;
Hauser, Russ .
CURRENT OPINION IN PEDIATRICS, 2013, 25 (02) :247-254
[6]   Prenatal Tobacco Smoke Exposure Is Associated with Childhood DNA CpG Methylation [J].
Breton, Carrie V. ;
Siegmund, Kimberly D. ;
Joubert, Bonnie R. ;
Wang, Xinhui ;
Qui, Weiliang ;
Carey, Vincent ;
Nystad, Wenche ;
Haberg, Siri E. ;
Ober, Carole ;
Nicolae, Dan ;
Barnes, Kathleen C. ;
Martinez, Fernando ;
Liu, Andy ;
Lemanske, Robert ;
Strunk, Robert ;
Weiss, Scott ;
London, Stephanie ;
Gilliland, Frank ;
Raby, Benjamin .
PLOS ONE, 2014, 9 (06)
[7]   Associations of long interspersed nuclear element-1 DNA methylation with preterm birth in a prospective cohort study [J].
Burris, H. H. ;
Rifas-Shiman, S. L. ;
Baccarelli, A. ;
Tarantini, L. ;
Boeke, C. E. ;
Kleinman, K. ;
Litonjua, A. A. ;
Rich-Edwards, J. W. ;
Gillman, M. W. .
JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE, 2012, 3 (03) :173-181
[8]   Small-for-Gestational Age and Preterm Birth Across Generations: A Population-Based Study of Illinois Births [J].
Castrillio, Stephanie M. ;
Rankin, Kristin M. ;
David, Richard J. ;
Collins, James W., Jr. .
MATERNAL AND CHILD HEALTH JOURNAL, 2014, 18 (10) :2456-2464
[9]  
Coley SL, 2015, INT J POPUL RES, V2015
[10]  
Collins JW, 2007, ETHNIC DIS, V17, P113