Involvement of 5-HT1A receptor mechanisms in the inhibitory effects of methamphetamine on photic responses in the rodent suprachiasmatic nucleus

被引：6
|
作者：
Moriya, T
Yamanouchi, S
Fukushima, T
Shimazoe, T
Shibata, S
Watanabe, S
机构：
[1] WASEDA UNIV,SCH HUMAN SCI,DEPT PHARMACOL,TOKOROZAWA,SAITAMA 359,JAPAN
[2] KYUSHU UNIV,DEPT PHARMACOL,FAC PHARMACEUT SCI,FUKUOKA 81282,JAPAN
来源：
BRAIN RESEARCH | 1996年 / 740卷 / 1-2期
关键词：
circadian rhythm; suprachiasmatic nucleus; methamphetamine; NAN-190; 5-HT1A receptor; serotonin;
D O I：
10.1016/S0006-8993(96)00860-8
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
We examined the role of serotonin IA (5-HT1A) receptors in the inhibitory effects of methamphetamine (MA) on photic entrainment to the circadian pacemaker in the suprachiasmatic nucleus (SCN) of rodents. MA inhibited optic nerve stimulation-evoked field potential in the SCN, light-induced Fos expression in the SCN and light-induced phase shift of hamster wheel-running rhythm. NAN-190, a 5-HT1A receptor antagonist, eliminated the inhibitory effects of MA. NAN-190 has also been reported to antagonize alpha 1 adrenergic receptors. However, prazosin, which selectively antagonizes alpha(1) adrenergic receptors, did not affect the inhibitory action of RIA on light-induced Fos expression. In addition, parachloroamphetamine, which is known to be a 5-HT releaser, dose-dependently inhibited light-induced phase shift of wheel-running rhythm. These findings suggest that elevation of endogenous 5-HT levels by RIA inhibits the photic entraining responses of the circadian pacemaker in the SCN via 5-HT1A receptor stimulation of the 5-HT released by MA.
引用
收藏
页码：261 / 267
页数：7
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