Quantitative 35Cl Nuclear Quadrupole Resonance in Tablets of the Antidiabetic Medicine Diabinese

被引：10

作者：

Tate, Elizabeth ^{[1
]}

Althoefer, Kaspar ^{[1
]}

Barras, Jamie ^{[1
]}

Rowe, Michael D. ^{[1
]}

Smith, John A. S. ^{[1
]}

Pearce, Gareth E. S. ^{[2
]}

Wren, Stephen A. C. ^{[3
]}

机构：

[1] Kings Coll London, Dept Mech Engn, London WC2R 2LS, England

[2] Merck Sharp & Dohme Ltd, Hoddesdon EN11 9BU, Herts, England

[3] AstraZeneca, Macclesfield SK10 2NA, Cheshire, England

来源：

ANALYTICAL CHEMISTRY | 2009年 / 81卷 / 13期

关键词：

D O I：

10.1021/ac900656e

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Pulsed Cl-35 nuclear quadrupole resonance (NQR) experiments have been performed on 250-mg tablets of the antidiabetic medicine Diabinese to establish the conditions needed for noninvasive quantitative analysis of the medicine in standard bottles. One important condition is the generation of a uniform radio-frequency (RF) field over the sample, which has been achieved by two designs of sample coil: one of variable pitch, and the other a resonator that has been fabricated from a single turn of copper sheet with a longitudinal gap bridged by tuning capacitors. The results from blind tests show that the number of tablets in a bottle could be predicted to within +/- 3%.

引用

页码：5574 / 5576

页数：3

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