The synthesis of biocompatible and SERS-active gold nanoparticles using chitosan

被引：74
作者：
Potara, Monica [1 ]
Maniu, Dana
Astilean, Simion
机构：
[1] Univ Babes Bolyai, Nanobiophoton Lab, Inst Interdisciplinary Expt Res, Cluj Napoca 400084, Romania
来源：
NANOTECHNOLOGY | 2009年 / 20卷 / 31期
关键词：
METAL NANOPARTICLES; RAMAN-SCATTERING; SURFACE-PLASMON; BIOSYNTHESIS; REDUCTION; CHEMISTRY; CHAINS;
D O I：
10.1088/0957-4484/20/31/315602
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
In this study we present a clean, nontoxic, environmentally friendly synthesis procedure to generate a large variety of gold nanoparticles (GNPs) by using chitosan, a biocompatible, biodegradable, natural polymer, as reducing and stabilizing agent. The formation of gold-chitosan nanocomposites was characterized by UV-vis absorption spectroscopy, transmission electron microscopy (TEM), x-ray diffraction (XRD) and Raman spectroscopy. The results show that the reaction temperature plays a crucial role in controlling the size, shape and crystalline structure of GNPs. In addition, it is demonstrated that chitosan can perform as a scaffold for the assembly of GNPs, which were successfully applied as substrate for surface-enhanced Raman scattering (SERS). To test the SERS activity, a relevant biological molecule-tryptophan-was adopted as the analyte.
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页数：7
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