From IL-10 to IL-12: how pathogens and their products stimulate APCs to induce TH1 development

被引：130

作者：

O'Garra, Anne ^{[1
]}

Murphy, Kenneth M. ^{[2
,3
]}

机构：

[1] Natl Inst Med Res, MRC, Div Immunoregulat, London NW7 1AA, England

[2] Washington Univ, Sch Med, Dept Pathol, St Louis, MO 63110 USA

[3] Washington Univ, Sch Med, Howard Hughes Med Inst, Ctr Immunol, St Louis, MO 63110 USA

来源：

NATURE IMMUNOLOGY | 2009年 / 10卷 / 09期

基金：

英国医学研究理事会;

关键词：

INHIBITS CYTOKINE PRODUCTION; INTERFERON-GAMMA PRODUCTION; CD4+ T-CELLS; TH1; CELLS; PHENOTYPE DEVELOPMENT; DENDRITIC CELLS; INTERLEUKIN-10; MACROPHAGES; CLONES; GENE;

D O I：

10.1038/ni0909-929

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The authors recount their discovery of how pathogen-induced interleukin 12 production leads to T(H)1 T cell polarization. Simultaneously they discovered the suppressive cytokine interleukin 10 inhibits antigen-presenting cells, thus regulating development of T(H)1 cells.

引用

页码：929 / 932

页数：4

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