From IL-10 to IL-12: how pathogens and their products stimulate APCs to induce TH1 development

被引：130

作者：

O'Garra, Anne ^{[1
]}

Murphy, Kenneth M. ^{[2
,3
]}

机构：

[1] Natl Inst Med Res, MRC, Div Immunoregulat, London NW7 1AA, England

[2] Washington Univ, Sch Med, Dept Pathol, St Louis, MO 63110 USA

[3] Washington Univ, Sch Med, Howard Hughes Med Inst, Ctr Immunol, St Louis, MO 63110 USA

来源：

NATURE IMMUNOLOGY | 2009年 / 10卷 / 09期

基金：

英国医学研究理事会;

关键词：

INHIBITS CYTOKINE PRODUCTION; INTERFERON-GAMMA PRODUCTION; CD4+ T-CELLS; TH1; CELLS; PHENOTYPE DEVELOPMENT; DENDRITIC CELLS; INTERLEUKIN-10; MACROPHAGES; CLONES; GENE;

D O I：

10.1038/ni0909-929

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The authors recount their discovery of how pathogen-induced interleukin 12 production leads to T(H)1 T cell polarization. Simultaneously they discovered the suppressive cytokine interleukin 10 inhibits antigen-presenting cells, thus regulating development of T(H)1 cells.

引用

页码：929 / 932

页数：4

共 50 条

[21] MEK1 dependent and independent ERK activation regulates IL-10 and IL-12 production in bone marrow derived macrophages
Bouhamdan, Mohamad
Bauerfeld, Christian
Talreja, Jaya
Beuret, Laurent
Charron, Jean
Samavati, Lobelia
CELLULAR SIGNALLING, 2015, 27 (10) : 2068 - 2076
[22] IL-12/Th1 and IL-23/Th17 Biliary Microenvironment in Primary Biliary Cirrhosis: Implications for Therapy
Yang, Chen-Yen
Ma, Xiong
Tsuneyama, Koichi
Huang, Shanshan
Takahashi, Toru
Chalasani, Naga P.
Bowlus, Christopher L.
Yang, Guo-Xiang
Leung, Patrick S. C.
Ansari, Aftab A.
Wu, Linda
Coppel, Ross L.
Gershwin, M. Eric
HEPATOLOGY, 2014, 59 (05) : 1944 - 1953
[23] Expression of cytokines Th1 (IL-2, IL-12, IFN-γ, TNF-α), Th2 (IL-4, IL-10, TGF-β) and Th17 (IL-17) in circulating lymphocytes of guinea pigs inoculated with a field strain of Salmonella Typhimurium
Mejia, David
Salvatierra, Guillermo
Maximiliano, Jorge
Rimac, Rocio
Carhuaricra, Dennis
Almeyda, Marcos
Luna, Luis
Rosadio, Raul
Maturrano, Lenin
REVISTA DE INVESTIGACIONES VETERINARIAS DEL PERU, 2019, 30 (04): : 1750 - 1761
[24] The multikinase inhibitor Sorafenib reverses the suppression of IL-12 and enhancement of IL-10 by PGE2 in murine macrophages
Edwards, Justin P.
Emens, Leisha A.
INTERNATIONAL IMMUNOPHARMACOLOGY, 2010, 10 (10) : 1220 - 1228
[25] IL-12B and IL-10 gene polymorphisms in the development of Hashimoto's thyroiditis
Gerenova, J.
Stanilova, S.
INTERNATIONAL JOURNAL OF IMMUNOGENETICS, 2016, 43 (06) : 397 - 403
[26] Murine immunomodulation of IL-10 and IL-12 induced by new isolates from avian type 2 Lactobacillus acidophilus
Bleau, Christian
Savard, Roland
Lamontagne, Lucie
CANADIAN JOURNAL OF MICROBIOLOGY, 2007, 53 (08) : 944 - 956
[27] The vaccine adjuvant alum promotes IL-10 production that suppresses Th1 responses
Oleszycka, Ewa
McCluskey, Sean
Sharp, Fiona A.
Munoz-Wolf, Natalia
Hams, Emily
Gorman, Aoife L.
Fallon, Padraic G.
Lavelle, Ed C.
EUROPEAN JOURNAL OF IMMUNOLOGY, 2018, 48 (04) : 705 - 715
[28] Construction of internal cDNA competitors for measuring IL-10 and IL-12 cytokine gene expression in swine
Mansfield, LS
Urban, JF
Holley-Shanks, RR
Murtaugh, MP
Zarlenga, DS
Foss, D
Canals, A
Gause, W
Lunney, JK
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 1998, 65 (01) : 63 - 74
[29] Mechanical deformation inhibits IL-10 and stimulates IL-12 production by mouse calvarial osteoblasts in vitro
García-López, S
Meikle, MC
Villanueva, RE
Montaño, L
Massó, F
Ramírez-Amador, V
Bojalil, R
ARCHIVES OF ORAL BIOLOGY, 2005, 50 (04) : 449 - 452
[30] Endogenous il-12 regulates the th1 immune response in experimental sporothrix schenckii infection
Flores-Garcia, A.
Garibaldi-Becerra, V
Barba-Barajas, M.
Velarde-Felix, J. S.
Wong-Ley-Madero, L. E.
Aguiar-Garcia, P.
Ramos-Zepeda, R.
8TH JOINT CONFERENCE OF THE INTERNATIONAL CYTOKINE SOCIETY AND THE INTERNATIONAL SOCIETY FOR INTERFERON AND CYTOKINE RESEARCH, 2010, : 7 - 11

← 1 2 3 4 5 →