From IL-10 to IL-12: how pathogens and their products stimulate APCs to induce TH1 development

被引：130

作者：

O'Garra, Anne ^{[1
]}

Murphy, Kenneth M. ^{[2
,3
]}

机构：

[1] Natl Inst Med Res, MRC, Div Immunoregulat, London NW7 1AA, England

[2] Washington Univ, Sch Med, Dept Pathol, St Louis, MO 63110 USA

[3] Washington Univ, Sch Med, Howard Hughes Med Inst, Ctr Immunol, St Louis, MO 63110 USA

来源：

NATURE IMMUNOLOGY | 2009年 / 10卷 / 09期

基金：

英国医学研究理事会;

关键词：

INHIBITS CYTOKINE PRODUCTION; INTERFERON-GAMMA PRODUCTION; CD4+ T-CELLS; TH1; CELLS; PHENOTYPE DEVELOPMENT; DENDRITIC CELLS; INTERLEUKIN-10; MACROPHAGES; CLONES; GENE;

D O I：

10.1038/ni0909-929

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The authors recount their discovery of how pathogen-induced interleukin 12 production leads to T(H)1 T cell polarization. Simultaneously they discovered the suppressive cytokine interleukin 10 inhibits antigen-presenting cells, thus regulating development of T(H)1 cells.

引用

页码：929 / 932

页数：4

共 50 条

[11] Seminal Levels of IL-10, IL-12, and IL-17 in Men with Asymptomatic Chlamydia Infection
Hakimi, Hamid
Akhondi, Mohammad Mehdi
Sadeghi, Mohammad Reza
Chamani, Leila
Arababadi, Mohammad Kazemi
Ahmadabadi, Behzad Nasiri
Hassanshahi, Gholamhossein
Fathollahi, Mahmoud Sheikh
INFLAMMATION, 2014, 37 (01) : 122 - 126
[12] Regulation of the IL-10/IL-12 axis in human dendritic cells with probiotic bacteria
Gad, Monika
Ravn, Peter
Soborg, Ditte A.
Lund-Jensen, Karina
Ouwehand, Arthur C.
Jensen, Simon S.
FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY, 2011, 63 (01): : 93 - 107
[13] Identification of a rat bone marrow-derived dendritic cell population which secretes both IL-10 and IL-12: Evidence against a reciprocal relationship between IL-10 and IL-12 secretion
Muthana, Munitta
Fairburn, Barbara
Mirza, Shabana
Slack, Laura K.
Hopkinson, Kay
Pockley, Alan G.
IMMUNOBIOLOGY, 2006, 211 (05) : 391 - 402
[14] Principal role of IL-12p40 in the decreased Th1 and Th17 responses driven by dendritic cells of mice lacking IL-12 and IL-18
Lim, Hui Xuan
Hong, Hye-Jin
Jung, Mi Young
Cho, Daeho
Kim, Tae Sung
CYTOKINE, 2013, 63 (02) : 179 - 186
[15] Regulation of T cell-dependent and -independent IL-12 production by the three Th2-type cytokines IL-10, IL-6, and IL-4
Takenaka, H
Maruo, S
Yamamoto, N
Wysocka, M
Ono, S
Kobayashi, M
Yagita, H
Okumura, K
Hamaoka, T
Trinchieri, G
Fujiwara, H
JOURNAL OF LEUKOCYTE BIOLOGY, 1997, 61 (01) : 80 - 87
[16] c-Jun Controls the Ability of IL-12 to Induce IL-10 Production from Human Memory CD4+ T Cells
Garcia, Carlos A.
Wang, Huizhi
Benakanakere, Manjunatha R.
Barrett, Elyse
Kinane, Denis F.
Martin, Michael
JOURNAL OF IMMUNOLOGY, 2009, 183 (07) : 4475 - 4482
[17] Bile acids PKA-dependently induce a switch of the IL-10/IL-12 ratio and reduce proinflammatory capability of human macrophages
Haselow, Katrin
Bode, Johannes G.
Wammers, Marianne
Ehlting, Christian
Keitel, Verena
Kleinebrecht, Laura
Schupp, Anna-Kathrin
Haeussinger, Dieter
Graf, Dirk
JOURNAL OF LEUKOCYTE BIOLOGY, 2013, 94 (06) : 1253 - 1264
[18] Induced and spontaneous colitis mouse models reveal complex interactions between IL-10 and IL-12/IL-23 pathways
Hurtubise, Raphael
Audiger, Cindy
Dominguez-Punaro, Maria C.
Chabot-Roy, Genevieve
Chognard, Gaelle
Raymond-Marchand, Laurence
Coderre, Lise
Chemtob, Sylvain
Michnick, Stephen W.
Rioux, John D.
Lesage, Sylvie
CYTOKINE, 2019, 121
[19] Serum Cytokine of IL-10 and IL-12 in Chronic Liver Disease: The Immune and Inflammatory Response
El-Emshaty, Hoda Mohamed
Nasif, Wesam Ahmad
Mohamed, Ibrahim Eldsoky
DISEASE MARKERS, 2015, 2015
[20] mTOR signaling pathway regulates the IL-12/IL-10 axis in Leishmania donovani infection
Cheekatla, Satyanarayana Swamy
Aggarwal, Amita
Naik, Sita
MEDICAL MICROBIOLOGY AND IMMUNOLOGY, 2012, 201 (01) : 37 - 46

← 1 2 3 4 5 →